56866-55-8

Basic information

• Product Name: ethyl 2-amino-3-(3-(benzyloxy)phenyl)propanoate
• Synonyms: ethyl 2-amino-3-(3-(benzyloxy)phenyl)propanoate
• CAS NO: 56866-55-8
• Molecular Weight: 299.37
• Mol File: 56866-55-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-amino-3-(3-(benzyloxy)phenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-amino-3-(3-(benzyloxy)phenyl)propanoate(56866-55-8)
• EPA Substance Registry System: ethyl 2-amino-3-(3-(benzyloxy)phenyl)propanoate(56866-55-8)

Safety Data

• Hazardous Substances Data: 56866-55-8(Hazardous Substances Data)

Upstream product

• 881672-69-1 diethyl [3-(benzyloxy)benzyl]malonate 
• 1313214-02-6 ethyl 3-(3-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanoate 
• 1313214-01-5 ethyl 2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propanoate 
• 35532-01-5 ethyl 2-amino-3-(3-hydroxyphenyl)propanoate hydrochloride 
• 775-06-4 D/L-3-hydroxy-phenylalanine 

Downstream Products

• 1313214-03-7 ethyl 3-(3-(benzyloxy)phenyl)-2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)propanoate 

Relevant articles and documents

Unnatural α-amino ethyl esters from diethyl malonate or ethyl β-bromo-α-hydroxyiminocarboxylate

We have explored here the scope of the age-old diethyl malonate-based accesses to α-amino esters involving Knoevenagel condensations of diethyl malonate on aldehydes, reductions of the resulting alkylidenemalonates, the preparation of the corresponding α-hydroxyimino esters and their final reduction. This synthetic pathway turned out to be general although some unexpected limitations were encountered. The synthetic modifications of some of the intermediates - using Suzuki-Miyaura coupling or cycloadditions - before undertaking the oximation step - provided accesses to further α-amino esters. Moreover, other pathways to α-hydroxyimino esters were explored including an attempt to improve the cycloadditions between ethyl β-bromo-α-hydroxyiminocarboxylate and various alkylfuranes.