56866-55-8

Upstream product

• 775-06-4 D/L-3-hydroxy-phenylalanine 
• 35532-01-5 ethyl 2-amino-3-(3-hydroxyphenyl)propanoate hydrochloride 
• 1313214-01-5 ethyl 2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propanoate 
• 1313214-02-6 ethyl 3-(3-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanoate 
• 881672-69-1 diethyl [3-(benzyloxy)benzyl]malonate 

Downstream Products

• 1313214-03-7 ethyl 3-(3-(benzyloxy)phenyl)-2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)propanoate 

Relevant academic research and scientific papers

Unnatural α-amino ethyl esters from diethyl malonate or ethyl β-bromo-α-hydroxyiminocarboxylate

We have explored here the scope of the age-old diethyl malonate-based accesses to α-amino esters involving Knoevenagel condensations of diethyl malonate on aldehydes, reductions of the resulting alkylidenemalonates, the preparation of the corresponding α-hydroxyimino esters and their final reduction. This synthetic pathway turned out to be general although some unexpected limitations were encountered. The synthetic modifications of some of the intermediates - using Suzuki-Miyaura coupling or cycloadditions - before undertaking the oximation step - provided accesses to further α-amino esters. Moreover, other pathways to α-hydroxyimino esters were explored including an attempt to improve the cycloadditions between ethyl β-bromo-α-hydroxyiminocarboxylate and various alkylfuranes.

NEW INHIBITORS OF CYCLOPHILINS AND USES THEREOF

The present invention relates to a compound of formula (I): Formula (I), wherein: - n is 0, 1 or 2; - A is in particular CH or N; - X is in particular CO, SO2, CS, and R1 is in particular H, - R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particular H, and R5 an alkyl group, - R6 is in particular H or an alkyl group, and - R7 is in particular an aryl group, for its use in the prevention and/or the treatment of viral pathologies or infections.