56875-38-8

Upstream product

• 122-52-1 triethyl phosphite 
• 626-15-3 1,3-bis-(bromomethyl)benzene 
• 626-16-4 3-(chloromethyl)benzyl chloride 

Downstream Products

• 144052-40-4 meta-xylene-α,α'-diphosphonic acid 
• 862378-60-7 1,3-bis-phosphanylmethyl-benzene 
• 930284-63-2 (E,E)-2,6-bis(3-methoxy-4-aminostyryl)benzene 
• 930284-67-6 (E,E)-2,6-bis(3-amino-4-methoxystyryl)benzene 
• 114468-34-7 1,1'-{1,3-phenylenebis[(E)-ethene-2,1-diyl]}bis(3,4-dimethoxybenzene) 
• 1725-76-4 (E,E)-1,3-distyrylbenzene 
• 1236355-33-1 (E,E)-3,5-bis-(3'-hydroxy-4'-methoxystyryl)benzene 
• 1396039-76-1 (E,E)-3,5-bis-(3'-hydroxystyryl)benzene 
• 1396037-45-8 (E,E)-3,5-bis(3'-methoxymethoxystyryl)benzene 
• 849434-20-4 (E,E)-3,5-bis-(4'-hydroxy-3'-methoxystyryl)benzene 
• 1396037-49-2 (E,E)-3,5-bis(3'-methoxy-4'-methoxymethoxystyryl)benzene 
• 1396037-62-9 (E,E)-3,5-bis(3'-methoxymethoxy-4'-N,N-dimethylaminostyryl)benzene 
• 1396037-57-2 (E,E)-3,5-bis(4'-methoxymethoxy-3'-N,N-dimethylaminostyryl)benzene 
• 1202480-76-9 (E,E)-3,5-bis-(4'-hydroxystyryl)benzene 

Relevant academic research and scientific papers

BIS-BUTADIENE DERIVATIVE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER

A bis-butadiene derivative is represented by general formula (1) shown below. In general formula (1), Ra, Rb, and Rc each represent, independently of one another, an alkyl group having a carbon number of at least 1 and no greater than 8 or an alkoxy group

Turn-on fluorescence sensor for mono- and di-phosphonic acid derivatives using anthracene-based diamidine and its detection of amidinium-phosphonate and amidinium formation

The fluorescence detection of di-phosphonic acid and mono-phosphonic acid derivatives using the anthracene-based diamidine 1 has been investigated. The diamidine 1 forms 1:1 and 1:2 complexes with the di-phosphonic acid and mono-phosphonic acid derivative

PH-dependent syntheses, luminescence and magnetic properties of two-dimensional framework lanthanide 1,3-diarylphosphonate complexes

A series of novel organic-inorganic complexes based on trivalent lanthanides and 1,3-C6H4[CH2P(O)(OH) 2]2 (H4L) formulated as Ln(HL)(H 2O)2 (Ln = La, 1; Pr, 2; Nd, 3;

Small molecules that protect against β-amyloid-induced cytotoxicity by inhibiting aggregation of β-amyloid

Aggregated β-amyloid (Aβ) plays crucial roles in Alzheimer's disease (AD) pathogenesis, therefore blockade of Aβ aggregation is considered as a potential therapeutic target. We designed and synthesized small molecules to reduce Aβ-induced cytotoxicity by inhibiting Aβ aggregation. The small molecules were screened via ThT, MTT, and cell-based cytotoxicity assay (Aβ burden assay). Selected compounds 1c, 1d, 1e, and 1f were then investigated by evaluating their effects on cognitive impairment of acute AD mice model. Learning and memory dysfunction by injection of Aβ(1-42) was recovered by administration of these molecules. Especially, 1d showed the best recovery activity in Y-maze task, object recognition task, and passive avoidance task with dose dependent manner. These results suggest that 1d has high potential as a therapeutic agent for AD.

Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers

Starting from bisphenolic bis-styrylbenzene DF-9 (4), β-amyloid (Aβ) binding affinity and specificity for phenolic bis-styrylbenzenes, monostyrylbenzenes, and alkyne controls were determined by fluorescence titration with β-amyloid peptide Aβ1-40 and a fluorescence assay using APP/PS1 transgenic mouse brain sections. Bis-styrylbenzene SAR is derived largely from work on symmetrical compounds. This study is the first to describe Aβ binding data for bis-styrylbenzenes unsymmetrical in the outer rings. With one exception, binding affinity and specificity were decreased by adding and/or changing the substitution pattern of phenol functional groups, changing the orientation about the central phenyl ring, replacing the alkene with alkyne bonds, or eliminating the central phenyl ring. The only compound with an Aβ binding affinity and specificity comparable to 4 was its 3-hydroxy regioisomer 8. Like 4, 8 crossed the blood-brain barrier and bound to Aβ plaques in vivo. By use of a DPPH assay, phenol functional groups with para orientations seem to be a necessary, but insufficient, criterion for good free radical scavenging properties in these compounds.

BIS(STYRYL)PYRIMIDINE OR BIS(STYRYL)BENZENE COMPOUNDS, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DISEASES FEATURING AMYLOIDS COMPRISING THE SAME AS AN ACTIVE INGRED

Disclosed are bis(styryl)pyrimidine or bis(styryl)benzene compounds, represented by Chemical Formula 1, pharmaceutically acceptable salts, a method for preparing the same, and a pharmaceutical composition for the prevention and treatment of amyloidosis-as

Synthesis of rigid π-conjugated mono-, bis-, tris-, and tetrakis(terpyridine)s: Influence of the degree and pattern of substitution on the photophysical Properties

A series of rigid π-conjugated mono-, bis-, tris-, and tetrakis-(terpyridine)s 3-8 was synthesized in high yields by means of Horner-Wadsworth-Emmons (HWE) reactions between benzyl phosphonates 1 and an aldehyde-functionalized ter-pyridine derivative 2. The photophysical properties of the materials in solution and in the solid state depend strongly both on the numbers of terpyridine moieties attached to the central phenyl cores and on the geometries of the compounds. The photophysical behavior of the ortho-substituted compounds 5 and 8 indicated significant changes in the geometries, together with major extensions of the effective π-conjugated systems upon excitation. Bright green emission with high quantum yields was observed for the tetrakis(ter-pyridine) derivative 8.

Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation

New bis-styrylpyridine and bis-styrylbenzene derivatives were designed and synthesized. These 34 compounds were evaluated by Aβ fibril formation inhibitory assay using thioflavin T as a dye (named ThT assay). Most of them showed excellent inhibitory activ

STILBENE DERIVATIVE, METHOD FOR PRODUCING THE SAME AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR

PROBLEM TO BE SOLVED: To provide a stilbene derivative having sensitivity characteristics and durability by possessing a naphthylenediamine structure at the molecular terminal, to provide a method for producing the same and to provide an electrophotograph

Polyaromatic amines. Part 3: Synthesis of poly(diarylamino)styrenes and related compounds

The title compounds were synthesised and characterised as part of a study into new aromatic amines for charge transporting materials. Compounds 12-16, 20-24 and 27-34 are alkene linked triarylamines, compounds 35-36 are hydrazone derivatives and compounds 38-41 are pyrrole substituted triarylamines. Each compound was characterised by cyclic voltammetry.