56876-28-9Relevant academic research and scientific papers
Antileukemic activity of tetrazole analogs of phenylalanine derivatives
Darling
, p. 356 - 358 (1982)
Eleven tetrazole analogs of substituted phenylalanines were prepared and tested for antitumor activity using P-388 lymphocytic leukemia cells in mice. None of the compounds exhibited significant activity (T/C%, 125).
α-Amino Acid-Isosteric α-Amino Tetrazoles
Zhao, Ting,Kurpiewska, Katarzyna,Kalinowska-T?us?cik, Justyna,Herdtweck, Eberhardt,D?mling, Alexander
, p. 3009 - 3018 (2016/03/26)
The synthesis of all 20 common natural proteinogenic and 4 otherα-amino acid-isosteric α-amino tetrazoles has been accomplished, whereby the carboxyl group is replaced by the isosteric 5-tetrazolyl group. The short process involves the use of the key Ugi tetrazole reaction followed by deprotection chemistries. The tetrazole group is bioisosteric to the carboxylic acid and is widely used in medicinal chemistry and drug design. Surprisingly, several of the common α-amino acid-isosteric α-amino tetrazoles are unknown up to now. Therefore a rapid synthetic access to this compound class and non-natural derivatives is of high interest to advance the field.
