56885-28-0

Usage

Physical properties

Colorless, odorless gas

Common uses

Refrigerant, propellant in aerosol products

Environmental impact

Lower ozone depletion potential, greenhouse gas, contributor to global warming

Safety classification

Hazardous material, requires careful handling and storage to prevent harm to human health and the environment

Upstream product

• 56885-29-1 1,2,2,2-tetrafluoroethyl dichloromethyl ether 
• 172103-17-2 (R,S)-1,2,2,2-Tetrafluoroethyl dichlorofluoromethyl ether 

Relevant academic research and scientific papers

Production Method for 1,2,2,2-Tetrafluoroethyl Difluoromethyl Ether (Desflurane)

Fluoral is obtained by gas-phase fluorination of chloral in the presence of a catalyst and then reacted with trimethyl orthoformate, thereby readily forming 1,2,2,2-tetrafluoroethyl methyl ether as an intermediate for production of desflurane. 1,2,2,2-Tetrafluoroethyl difluoromethyl ether (desflurane) is produced with high yield from the thus-formed 1,2,2,2-tetrafluoroethyl methyl ether by chlorination and fluorination. This method enables efficient industrial-scale production of desflurane useful as an inhalation anesthetic

Asymmetric Synthesis of the Volatile Anesthetic 1,2,2,2-Tetrafluoroethyl Chlorofluoromethyl Ether Using a Stereospecific Decarboxylation of Unusual Stereochemical Outcome

Acid 1 is optically resolved by diastereomeric amide formation/chromatography/hydrolysis.Decarboxylaion of the enantiomers of acid 1 gives the enantiomers of ether 2 with a very high degree of stereospecificity.The absolute configurations of both the star