5689-99-6Relevant academic research and scientific papers
N-(3,5-DICHLOROPYRIDIN-4-YL)-2,4,5-ALKOXY AND 2,3,4-ALKOXY BENZAMIDE DERIVATIVES AS PDE-IV (PHOPHODIESTERASE TYPE-IV) INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES SUCH AS ASTHMA
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Page/Page column 16-17, (2010/11/08)
The present invention relates to benzamide derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV, having the structure of Formula (I), its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers of N-oxides wherein R1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heteroaryl, heterocyclyl, aralkyl, heterocyclylalkyl, heteroarylalkyl or cycloalkylalkyl; R2 is aryl, heteroaryl, heterocyclyl of cycloalkyl; and R3 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heteroaryl, heterocyclyl, aralkyl, heterocyclylalkyl, heteroarylalkyl or cycloalkylalkyl. Compounds disclosed herein can be useful in the treatment of inflammatory diseases, AIDS, asthma, arthritis, bronchitis, chronic obstructer pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn’ s disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis and ulcerative colitis.
