56898-60-3Relevant academic research and scientific papers
Phosphinic Amide as Directing Group Enabling Palladium(II)-Catalyzed ortho C-H Alkenylation of Anilines without and with Alkylation at the Nitrogen Atom
Jiao, Lin-Yu,Ferreira, André V.,Oestreich, Martin
supporting information, p. 367 - 370 (2016/05/19)
A phosphinic amide is introduced as a directing group for the ortho C-H alkenylation of anilines. The new donor group distinguishes itself from existing ones by assisting the C-H bond activation of anilides without (NH group) and with alkylation (NMe group) at the amide nitrogen atom. The reactivity is even reversed with the methyl-substituted anilide being more reactive than its unsubstituted counterpart. Electron-donating substituents at the arene ring enhance their reactivity while halogenation is not tolerated. The phosphinic amide also enables the C-7-selective C-H alkenylation of indoline.
SOME NEW PHOSPHINIC AMIDES R2P(O)NHR'
Brueck, A.,Kuchen, W.,Peters, W.
, p. 129 - 134 (2007/10/03)
P,P-Diorganylphosphinic amides R2P(O)NHR' (R = tBu, iPr, Ph; R' = Et, Pr, Cy, iPr, tBu, Ph, etc.) have been prepared by reaction of R2PCl with the corresponding lithiated amine followed by oxidation with H2O2.Th
