569-59-5 Usage
Uses
Used in Pharmaceutical Industry:
Phenindamine tartrate is used as an antihistamine for treating various allergic conditions, such as itching, hives, and rashes. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Used in Sleep Aid Applications:
Phenindamine tartrate is used as a sleep aid for inducing drowsiness and sleepiness in patients who have difficulty falling asleep or staying asleep. It is particularly useful for those who experience mild insomnia when taken just before bedtime.
Used in Branded Medications:
Phenindamine tartrate is used as an active ingredient in the brand-name medication Thephorin (Hoffmann-LaRoche), which is prescribed for the treatment of allergic conditions and sleep disorders.
Originator
Thephorin ,Roche, US,1947
Manufacturing Process
A mixture of 750 grams of 1-methyl-3-benzoyl-4-hydroxy-4-phenylpiperidine and 2,500 cc of 48% hydrobromic acid is refluxed for about 20 minutes. It is then poured into 8 liters of water. An oily precipitate appears which on standing crystallizes. It is filtered and crystallized from about 3.5 liters of alcohol. 2-Methyl-9-phenyl-2,3-dihydrel-pyridindene hydrobromide, MP 201°203°C, is obtained.A mixture of 680 grams of 2-methyl-9-phenyl-2,3-dihydrol-pyridindene hydrobromide, 6,000 cc of water and about 100 grams of Raney-nickel catalyst is hydrogenated at room temperature and at about 1,000 lb pressure for a period of three hours. The catalyst is filtered. The clear filtrate is treated with a solution of 240 grams potassium thiocyanate in 400 cc of water. A heavy solid precipitates from which the supernatant liquid is decanted.The residue is dissolved in 10 liters of boiling alcohol with stirring in the presence of nitro gen. The solution is cooled to room temperature under nitrogen, and then allowed to stand overnight. 2-Methyl-9-phenyl-tetrahydro1-pyridindene thiocyanate separates in crystals of MP 188°-189°C. From the concentrated filtrate an additional amount is obtained. The corresponding free base, prepared by treating the slightly soluble thiocyanate in aqueous suspension with sodium hydroxide and extracting with ether, has a MP of 90°91°C. It forms a tartrate of MP 160°C.The starting material was prepared by reacting acetophenone, methylamine and formaldehyde followed by treatment of the intermediate with sodium hydroxide.
Therapeutic Function
Antihistaminic
Check Digit Verification of cas no
The CAS Registry Mumber 569-59-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,6 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 569-59:
(5*5)+(4*6)+(3*9)+(2*5)+(1*9)=95
95 % 10 = 5
So 569-59-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H19N.C4H6O6/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14;5-1(3(7)8)2(6)4(9)10/h2-10,19H,11-13H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)
