5691-08-7

Usage

Uses

Used in Pharmaceutical Synthesis:
2-Pyridin-2-yl-1H-indole-3-carbaldehyde is used as a key intermediate in the synthesis of pharmaceuticals for its unique chemical properties. Its aromatic ring structure and functional groups contribute to the development of new drugs with potential therapeutic applications.
Used in Organic Material Synthesis:
In the field of organic materials, 2-Pyridin-2-yl-1H-indole-3-carbaldehyde is used as a building block for the creation of various organic compounds. Its versatility allows for the synthesis of a wide range of organic materials with different properties and applications.
Used in Medicinal Chemistry Research:
2-Pyridin-2-yl-1H-indole-3-carbaldehyde is utilized in medicinal chemistry research for its potential biological activities. Its unique structure and functional groups make it a promising candidate for the development of new therapeutic agents and the study of their mechanisms of action.
Used in Chemical Compound Design:
In the design of new chemical compounds, 2-Pyridin-2-yl-1H-indole-3-carbaldehyde serves as a valuable component due to its chemical properties and reactivity. It can be incorporated into various molecular structures to create novel compounds with specific functions and applications in different industries.

InChI:InChI=1/C14H10N2O/c17-9-11-10-5-1-2-6-12(10)16-14(11)13-7-3-4-8-15-13/h1-9,16H

Upstream product

• 119910-45-1 2-bromo-1H-indole-3-carbaldehyde 
• 13737-05-8 2-trimethylstannylpyridine 
• 13228-40-5 2-(2-pyridinyl)-1H-indole 
• 68-12-2 N,N-dimethyl-formamide 

Relevant academic research and scientific papers

Novel benzofuran-3-one indole inhibitors of PI3 kinase-α and the mammalian target of rapamycin: Hit to lead studies

A series of benzofuran-3-one indole phosphatidylinositol-3-kinases (PI3K) inhibitors identified via HTS has been prepared. The optimized inhibitors possess single digit nanomolar activity against p110α (PI3K-α), good pharmaceutical properties, selectivity versus p110γ (PI3K-γ), and tunable selectivity versus the mammalian target of rapamycin (mTOR). Modeling of compounds 9 and 32 in homology models of PI3K-α and mTOR supports the proposed rationale for selectivity. Compounds show activity in multiple cellular proliferation assays with signaling through the PI3K pathway confirmed via phospho-Akt inhibition in PC-3 cells.

Photochemical electrocyclisation of 3-vinylindoles to pyrido[2,3-a]-, pyrido[4,3-a]- and thieno[2,3-a]-carbazoles: Design, synthesis, DNA binding and antitumor cell cytotoxicity

In the context of the design and synthesis of DNA ligands, some new hetarene annelated carbazoles were synthesized. As lead structure the intercalating tetracyclic systems pyrido[2,3-a]- and pyrido[4,3-a]-carbazoles and in one case a thieno[2,3-a]-carbazo

Creation of new promoters for plant's root growth: its application for the syntheses of vulcanine and borreline, and for combating desertification at gobi desert in inner mongolia 1#

Abstract - Various new 2-substituted indole-3-carbaldehydes are prepared. Structurally related alkaloids, vulcanine and borreline, are synthesized as well. Among the compounds, 2-haloindole-3-carbaldehydes are found to be potent promoters of plant's root growth. Its successful preliminary application is reported for making Gobi desert in Inner Mongolia full of plant.

A CONVENIENT SYNTHETIC METHOD OF 2-SUBSTITUTED INDOLES AND ITS APPLICATION FOR THE SYNTHESIS OF NATURAL ALKALOID, BORRERINE

A simple synthetic method of 2-substituted indoles is developed.Total synthesis of natural alkaloid, borrerine, is also reported