56911-50-3Relevant academic research and scientific papers
Ozonation of ketoprofen with nitrate in aquatic environments: Kinetics, pathways, and toxicity
Zeng, Yongqin,Lin, Xiaoxuan,Li, Fuhua,Chen, Ping,Kong, Qingqing,Liu, Guoguang,Lv, Wenying
, p. 10541 - 10548 (2018)
In this study, nitrate ion (NO3-) was found to collaborate with ozone thereby accelerating the degradation of ketoprofen. NO3- was discovered to induce the generation of hydroxyl radicals (·OH), which was crucial to the decomposition of PPCPs in wastewater treatment plants. Kinetic studies on the decomposition of ketoprofen were investigated under different concentrations of NO3-. The impact mechanisms and degradation by-products were experimentally determined. The results revealed that all reactions fitted the pseudo-first-order kinetic model well. The presence of NO3- had the capacity to accelerate the ozonation of ketoprofen. The reaction by-products were evaluated by UPLC-Q-TOF-MS, and a total of five intermediates generated via the ozonation of ketoprofen were assessed. The transformation pathways were concluded to be hydroxylation, nitration, and debenzophenone and ketonized reactions. Additionally, the toxicity of the by-products was evaluated by employing Chlorella and Daphnia magna.
CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
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, (2009/10/09)
Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
Facile one-pot preparation of 2-arylpropionic and arylacetic acids from cyanohydrins by treatment with aqueous HI
Aramini, Andrea,Sablone, Manolo R.,Bianchini, Gianluca,Amore, Alessia,Fanì, Michela,Perrone, Plinio,Dolce, Alberto,Allegretti, Marcello
experimental part, p. 2015 - 2021 (2009/07/04)
A novel one-pot two-step procedure has been developed to synthesize highly substituted 2-arylpropionic and arylacetic acids, by treatment with aqueous HI, from cyanohydrins. The hydrogenolytic reduction of α-hydroxy-2-arylpropionic acids was the key step of the process and the optimization of the reaction conditions led to identify aqueous HI as an appropriate and selective reagent for the reductive deoxygenation of cyanohydrins. The synthetic route described a general and efficient strategy for the preparation of large libraries of phenylacetic and phenylpropionic acids derivatives.
Substituted phenols
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, (2008/06/13)
The present invention provides a colorimetric process for the detection of an oxidative coupling reaction in which a coupling component is reacted with a developer component in the presence of an oxidation agent to give a colored material, wherein, as coupling component, there is used a compound of the general formula: STR1 in which X is a bromine or chlorine atom, n is 1, 2 or 3, Y is COOR, CONRR', SO3 R, SO2 NRR', OR, NRR' or NRR'R"≈ and R, R' and R", independently of one another, are hydrogen atoms or C1 -C3 -alkyl radicals. The present invention also provides a reagent which contains the above compound, as well as new substituted phenols and a process for the preparation thereof.
M-phenoxyphenyl propionic acid derivatives and preparation thereof
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, (2008/06/13)
New meta-phenoxyphenyl propionic acid derivatives and pharmacologically acceptable salts thereof having excellent anti-inflammatory and analgesic activities with low toxicity are provided. The new compounds are adapted for therapeutical treatment of various inflammatory diseases by oral administration without injurious by-effects; successive administrations for an elongated period are not accompanied with an appreciable gastric irritability and the like.
