56919-56-3 Usage
Uses
Used in Pharmaceutical Research and Drug Development:
(Quinolin-2-ylsulfanyl)-acetic acid is used as a research compound for its potential biological activities. Its structural resemblance to quinoline-based drugs and the presence of a sulfhydryl group make it a promising candidate for the development of new pharmaceuticals.
Used in the Study of Biological Systems:
(Quinolin-2-ylsulfanyl)-acetic acid is used as a tool in the study of biological systems, particularly those involving thiols and quinoline derivatives. Its unique structure allows researchers to investigate various chemical reactions and interactions with biological molecules.
Used in Materials Science:
(Quinolin-2-ylsulfanyl)-acetic acid is used as a component in the development of new materials due to its unique structure and reactivity. Its potential applications in this field may include the creation of novel materials with specific properties or functions.
Used in Organic Synthesis:
(Quinolin-2-ylsulfanyl)-acetic acid is used as a reactant or intermediate in organic synthesis, where its quinoline ring and thiol group can be utilized to create a variety of complex organic compounds with potential applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 56919-56-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,9,1 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 56919-56:
(7*5)+(6*6)+(5*9)+(4*1)+(3*9)+(2*5)+(1*6)=163
163 % 10 = 3
So 56919-56-3 is a valid CAS Registry Number.
56919-56-3Relevant academic research and scientific papers
Ma, Yuqin,Luo, Qichao,Fu, Jie,Che, Yanxin,Guo, Fei,Mei, Lianghe,Zhang, Qiansen,Li, Yang,Yang, Huaiyu
, p. 10972 - 10983 (2020)
Modulators can be designed to stabilize the inactive and active states of ion channels, but whether intermediate (IM) states of channel gating are druggable remains underexplored. In this study, using molecular dynamics simulations of the TWIK-related potassium channel 1 (TREK-1) channel, a two-pore domain potassium channel, we captured an IM state during the transition from the down (inactive) state to the up (active-like) state. The IM state contained a druggable allosteric pocket that was not present in the down or up state. Drug design targeting the pocket led to the identification of the TKIM compound as an inhibitor of TREK-1. Using integrated methods, we verified that TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state. Overall, this study identified an allosteric ligand-binding site and a new mechanistic inhibitor for TREK-1, suggesting that IM states of ion channels may be promising druggable targets for use in discovering allosteric modulators.
