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• 74853-66-0 4'-trifluoromethyl-2,2,2-trifluoroacetophenone 

Downstream Products

• 58292-64-1 C₁₈H₈F₁₂N₂S 
• 58292-57-2 2,2,2-trifluoro-1-(4-trifluoromethyl-phenyl)-ethanone S-chloro-thiooxime 
• 56924-34-6 1-(2,2,2-trifluoro-1,1-diisocyanato-ethyl)-4-trifluoromethyl-benzene 
• 58292-65-2 2,2,2-trifluoro-1-(4-trifluoromethyl-phenyl)-ethanone S-morpholin-4-yl-thiooxime 

Relevant academic research and scientific papers

Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to N-Unprotected Ketimines: Efficient Synthesis of Cipargamin

Highly enantioselective rhodium-catalyzed addition of arylboroxines to N-unprotected ketimines is realized for the first time by employing chiral BIBOP-type ligands with a Rh loading as low as 1 mol %. A range of chiral α-trifluoromethyl-α,α-diaryl α-tertiary amines or 3-amino-3-aryloxindoles were formed with excellent ee values and yields by employing either WingPhos or PFBO-BIBOP as the ligand. The method has enabled an efficient enantioselective synthesis of cipargamin.

Tertiary amine compound, bisphosphine ligand, and intermediate and preparation method of tertiary amine compound

The invention discloses a tertiary amine compound, a bisphosphine ligand, and an intermediate and a preparation method of the tertiary amine compound, and provides a tertiary amine compound preparation method, which comprises: under the protection of a ga

Enantioselective Friedel–Crafts Alkylation Reaction of Heteroarenes with N-Unprotected Trifluoromethyl Ketimines by Means of Chiral Phosphoric Acid

An enantioselective Friedel–Crafts alkylation reaction of pyrroles and indoles with N-unprotected trifluoromethyl ketimines by use of chiral phosphoric acid provided α-trifluoromethylated primary amines bearing chiral tetrasubstituted carbon centers in high yields and with high to excellent enantioselectivities. The present reaction is unique to N-unprotected trifluoromethyl ketimines. No reaction took place with N-p-methoxyphenyl (PMP)-substituted ketimine. Corresponding α-trifluoromethylated amines were transformed without loss of enantioselectivity.