5693-36-7Relevant academic research and scientific papers
A highly active Cp*Ir complex with an anionic N,N-donor chelate ligand catalyzes the robust regeneration of NADH under physiological conditions
Qi, Caixia,Shi, Yusheng,Su, Huijuan,Sun, Libo,Sun, Wen,Sun, Xun,Xia, Linyan,Yin, Zequn,Zhang, Weiling,Zhao, Li-Jun
, p. 7982 - 7991 (2021/12/27)
A highly active [N^N?] iridium complex [Cp*Ir(pba)Cl] (3, Cp* = pentamethylcyclopentadiene, pba = 4-(picolinamido)benzoic acid) has been obtained with an anionic ligand, which exhibited the most robust performance for cofactor NADH regeneration in physiological conditions with HCOONa as the hydrogen source. The structure of complex3was revealed by X-ray single-crystal structure analysis. The turnover frequency (TOF) of complex3in the regeneration of NADH is 7825 h?1, which is about 22.7 times and 178 times higher than that of the C?^N type complex2(345 h?1) and N^N complex1(44 h?1) at 37 °C, respectively. The high activity of complex3seems to be critically affected by the negatively charged N?of the amide chelating ligand, which could promote the reaction rate of Ir-Cl conversion to Ir-H2O. Furthermore, complex3shows good biocompatibility for various biomolecules except SH-compounds (such as reduced glutathione (GSH)). When combined with NADH-dependent enzymes (KRED-101), the complex3-based NADH-regeneration catalytic system shows stable chemoenzymatical coordinate catalytic activity for reducing acetophenone to the corresponding alcohol with high enantioselectivity.
IMIDAZOPYRIDINE COMPOUND
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Page/Page column 46, (2008/06/13)
The present invention provides an imidazopyridine compound represented by formula (I), wherein R1 and R2 each independently represent a C1-6 alkyl group et al; R3 and R4 each independently represent a hydrogen atom, a methyl et al; Ar1 is a divalent substituent representing a monocyclic or bicyclic, 3- to 8-membered aromatic or aliphatic heterocyclic group et al; Ar2 represents an aromatic carbocyclic group, or an aromatic heterocyclic group; W represents -(CH2)m et al, and m indicates an integer of from 0 to 10. This compound acts as a melanin concentrating hormone receptor antagonist, and is useful as treating agents for obesity.
