569328-31-0Relevant articles and documents
Synthesis of isocryptolepine via a Pd-catalyzed 'amination-arylation' approach
Jonckers, Tim H. M.,Maes, Bert U. W.,Lemière, Guy L. F.,Rombouts, Geert,Pieters, Luc,Haemers, Achiel,Dommisse, Roger A.
, p. 615 - 618 (2003)
Isocryptolepine (cryptosanguinolentine) has been synthesized in three steps via a new approach starting from commercially available 4-chloroquinoline and 2-chloroaniline. The new methodology consists of two consecutive palladium-catalyzed reactions; a sel
Auto-tandem catalysis: Synthesis of substituted 11H-indolo [3,2-c]quinolines via palladium-catalyzed intermolecular C-N and intramolecular C-C bond formation
Meyers, Caroline,Rombouts, Geert,Loones, Kristof T. J.,Coelho, Alberto,Maes, Bert U. W.
supporting information; body text, p. 465 - 470 (2009/04/10)
D-Ring substituted 11H-indolo[3,2-c]quinolines (4) have been prepared via auto-tandem consecutive intermolecular Buchwald-Hartwig reaction and intramolecular palladium-catalyzed arylation on 4-chloroquinoline (1) with N-unsubstituted 2-chloroanilines (2).
Heteroatom directed photoannulation: synthesis of indoloquinoline alkaloids: cryptolepine, cryptotackieine, cryptosanguinolentine, and their methyl derivatives
Dhanabal,Sangeetha,Mohan
, p. 6258 - 6263 (2007/10/03)
A three-step synthesis of indoloquinoline alkaloids is described. The reaction of 2,3 and 4-substituted haloquinolines with anilines afforded the respective anilinoquinolines, which upon photocyclization gave the indoloquinolines. By regioselective methylation on quinoline nitrogen, furnished the alkaloids cryptotackieine, cryptosanguinolentine, cryptolepine, and the synthetic isomer isoneocryptolepine. Their methyl derivatives were also synthesized in search of new antiplasmodial drugs and DNA intercalating agents.
