569337-40-2Relevant academic research and scientific papers
Synthesis and biological activities of isogranulatimide analogues
Hugon, Bernadette,Anizon, Fabrice,Bailly, Christian,Golsteyn, Roy M.,Pierre, Alain,Leonce, Stephane,Hickman, John,Pfeiffer, Bruno,Prudhomme, Michelle
, p. 5965 - 5980 (2008/03/15)
The synthesis of new isogranulatimide analogues, their inhibitory activities toward the Checkpoint 1 kinase (Chk1), and their in vitro cytotoxicities toward four tumor cell lines (one murine L1210 leukemia, and three human cell lines: DU145 prostate carci
Synthesis of isogranulatimide analogues possessing a pyrrole moiety instead of an imidazole heterocycle
Hugon, Bernadette,Pfeiffer, Bruno,Renard, Pierre,Prudhomme, Michelle
, p. 3927 - 3930 (2007/10/03)
An efficient four step synthesis from commercial indoles of isogranulatimide analogues is reported. In the new compounds, the imidazole moiety is replaced by a pyrrole unit, the indole part is substituted or not in 5-position and the nitrogen of the imide moiety bears or not a methyl substituent.
