569337-85-5Relevant academic research and scientific papers
Synthesis of 3-(5-phenyl-1, 3,4-oxadiazol-2-yl)-2H-chromen-2-ones as anticonvulsant agents
Naga Sudha,Girija Sastry,Sai Harika,Yellasubbaiah
, p. 737 - 745 (2019/05/22)
3-(5-Phenyl-l,3,4-oxadiazol-2-yl)-2H-chromen-2-one (IVa-IVl) have been synthesized from N-benzylidene2-oxo-2#- chromene-3-carbohydrazide (IIIa-IIIl). The structure of synthesized coumarinyl oxadiazoles have been established by spectral data, elemental ana
Antitubercular activity of new coumarins
Cardoso, Silvia H.,Barreto, Milena B.,Lourenco, Maria C. S.,Henriques, Maria das Gracas M. De O.,Candea, Andre L. P.,Kaiser, Carlos R.,De Souza, Marcus V.N.
scheme or table, p. 489 - 493 (2012/01/13)
The present article describes a series of 21 N'-benzylidene-2-oxo-2H-chromene-3-carbohydrazides 4a-4v, which were synthesized and evaluated for their cell viabilities in non-infected and Mycobacterium bovis Bacillus Calmette-Guerin-infected macrophages. Subsequently, the non-cytotoxic compounds 4c, 4g, 4h, 4j, 4l and 4t were assessed against Mycobacterium tuberculosis ATCC 27294 using the microplate Alamar Blue assay and the activity expressed as the minimum inhibitory concentration in μg/mL. These compounds exhibited a significant activity (50-100μg/mL) when compared to the first-line drugs, such as pyrazinamide (PZA >100μg/mL). These results could be considered a good starting point for further studies to develop new lead compounds to treat multidrug-resistant tuberculosis. The present article describes a series of twenty-one coumarine derivatives, which were synthesized and evaluated against Mycobacterium tuberculosis.
Heterocyclic synthesis containing bridgehead nitrogen atom: Synthesis of 3-[(2H)- 2-oxobenzo[b]pyran-3-yl]-s-triazolo[3,4-b]-1,3,4-thiadiazine and thiazole derivatives
Raslan
, p. 114 - 120 (2007/10/03)
The reaction of 2H-2-oxobenzo[b]-pyran-3-hydrazide (2) with carbon disulfide in basic DMF afforded potassium thiocarbamate 3, which readily underwent heterocyclization upon its reaction with hydrazine and/or phenacyl bromide to yield 1,2,4-tiazole (4) and thiazole 7 derivatives, respectively. Condensation of 4 with substituted phenacyl bromide and/or chloranil gave 1,2,4-triazole[3,4-b]thiadiazine (5a,b) and 3,10-bis-[2H-2-oxobenzo[b]pyran-3-yl]-6,13-dichloro-bis-[2H-2-oxobenzo[b]pyran-3 -yl]- 6,13-dichloro-bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazino [5′,6′-b:5′,6′-e]cyclohexa-1,4-diene (6), respectively. Cyclization of thiosemicarbazide 10 by refluxing it in sodium hydroxide and/or phosphoryl chloride afforded triazole 13 and thiadiazole 15 derivatives, respectively. Also, 10 reacted with phenacyl bromide in the presence of anhydrous sodium acetate to give the oxothiazolidine derivative 17. The structure of the synthesized compounds were confirmed by elemental analyses, IR, 1H NMR, and mass spectra.
