569349-72-0

Basic information

• Product Name: α-[18F]fluoro-α'-bromo-m-xylene
• Synonyms: α-[18F]fluoro-α'-bromo-m-xylene
• CAS NO: 569349-72-0
• Molecular Weight: 202.056
• Mol File: 569349-72-0.mol

Chemical Properties

• CAS DataBase Reference: α-[18F]fluoro-α'-bromo-m-xylene(CAS DataBase Reference)
• NIST Chemistry Reference: α-[18F]fluoro-α'-bromo-m-xylene(569349-72-0)
• EPA Substance Registry System: α-[18F]fluoro-α'-bromo-m-xylene(569349-72-0)

Safety Data

• Hazardous Substances Data: 569349-72-0(Hazardous Substances Data)

Upstream product

• 626-15-3 1,3-bis-(bromomethyl)benzene 

Relevant articles and documents

Highly efficient one-pot labeling of new phosphonium cations with fluorine-18 as potential PET agents for myocardial perfusion imaging

Lipophilic cations such as phosphonium salts can accumulate in mitochondria of heart in response to the negative inner-transmembrane potentials. Two phosphonium salts [18F]FMBTP and [18F]mFMBTP were prepared and evaluated as potential myocardial perfusion imaging (MPI) agents in this study. The cations were radiolabeled via a simplified one-pot method starting from [18F]fluoride and followed by physicochemical property tests, in vitro cellular uptake assay, ex vivo mouse biodistribution, and in vivo rat microPET imaging. The total radiosynthesis time was less than 60 min including HPLC purification. The [18F] labeled compounds were obtained in high radiolabeling yield (～50%) and good radiochemical purity (>99%). Both compounds were electropositive, and their log P values at pH 7.4 were 1.16 ± 0.003 (n = 3) and 1.05 ± 0.01 (n = 3), respectively. Both [18F]FMBTP and [18F]mFMBTP had high heart uptake (25.24 ± 2.97% ID/g and 31.02 ± 0.33% ID/g at 5 min postinjection (p.i.)) in mice with good retention (28.99 ± 3.54% ID/g and 26.82 ± 3.46% ID/g at 120 min p.i.). From the PET images in rats, the cations exhibited high myocardium uptake and fast clearance from liver and small intestine to give high-contrast images across all time points. These phosphonium cations were radiosynthesized via a highly efficient one-pot procedure for potential MPI offering high heart accumulation and rapid nontarget clearance.

Radiosynthesis of 1-[18F]fluoromethyl-4-methyl-benzene and a series of o-, m- or p-substituted 1-halomethyl-[18F]fluoromethyl-benzenes

1-[18F]Fluoromethyl-4-methyl-benzene was prepared from its bromo analogue. Additionally, a number of o-, m- or p-substituted 1-halomethyl-[18F]fluoromethyl-benzenes were prepared by nucleophilic substitution reactions with [18F]fluoride on their dihalo analogues to provide new prospective bifunctional labelling agents.