56951-08-7Relevant articles and documents
Basically substituted 1,4-dihydro-2H-isoquinoline derivatives and process for preparing them
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, (2008/06/13)
1,4-Dihydro-2H-isoquinoline derivatives of the general formula I SPC1 in which R1 represents hydrogen or straight chain or branched alkyl of 1 to 6 carbon atoms, R2 represents low molecular dialkylaminoalkyl, in which both alkyl groups of the dialkylamino group together with the nitrogen atom may also form a 5-, 6- or 7-membered saturated ring in which one carbon atom may be substituted by an oxygen atom, a sulfur atom or another nitrogen atom which may be substituted by hydrogen, C1 -C4 -alkyl or phenyl, or R1 and R2 together may form a 5- or 6-membered saturated ring containing 1 nitrogen atom, R3 represents phenyl which may be mono- or di-substituted by halogen, nitro, amino or sulfamoyl, or acylamino or alkyl each containing 1 to 4 carbon atoms, or pyridyl R4 and R5, which may identical or different, represent hydrogen or alkoxy of 1 to 4 carbon atoms, and X represent oxygen or sulfur, Their physiologically tolerated salts, process for preparing them. The compounds are active on the coronary circulation and are distinguished in particular by an anti-arrhythmic action and may, therefore, be used in the treatment of disorders of the heart rhythm.
