56960-80-6Relevant academic research and scientific papers
ACETAMIDO DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS
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Paragraph 0199, (2020/08/22)
Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
COMBINATION THERAPY WITH MDM2 AND EFGR INHIBITORS
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Page/Page column 166, (2016/01/29)
Provided is a method of treating a proliferative disease, condition, or disorder in a subject by administering a combination of an inhibitor of p53 and MDM2 binding and an EGFR inhibitor. Various embodiments of the disclosed methods provide a synergistic
