56964-23-9Relevant articles and documents
Synthesis of Tridecaptin-Antibiotic Conjugates with in Vivo Activity against Gram-Negative Bacteria
Cochrane, Stephen A.,Li, Xuefeng,He, Sisi,Yu, Min,Wu, Min,Vederas, John C.
, p. 9779 - 9785 (2015)
A series of tridecaptin-antibiotic conjugates were synthesized and evaluated for in vitro and in vivo activity against Gram-negative bacteria. Covalently linking unacylated tridecaptin A1 (H-TriA1) to rifampicin, vancomycin, and erythromycin enhanced their activity in vitro but not by the same magnitude as coadministration of the peptide and these antibiotics. The antimicrobial activities of the conjugates were retained in vivo, with the H-TriA1-erythromycin conjugate proving a more effective treatment of Klebseilla pneumoniae infections in mice than erythromycin alone or in combination with H-TriA1.
Heterodimeric Rifampicin–Tobramycin conjugates break intrinsic resistance of Pseudomonas aeruginosa to doxycycline and chloramphenicol in vitro and in a Galleria mellonella in vivo model
Idowu, Temilolu,Arthur, Gilbert,Zhanel, George G.,Schweizer, Frank
, p. 16 - 32 (2019/04/25)
Intrinsic resistance in Pseudomonas aeruginosa, defined by chromosomally encoded low outer membrane permeability and constitutively over-expressed efflux pumps, is a major reason why the pathogen is refractory to many antibiotics. Herein, we report that h
Hydrazones of 3 formylrifamycin SV. Part I. Hydrazones with N amino N' substituted piperazines: synthesis, antibacterial activity and other biological properties
Cricchio,Arioli,Lancini
, p. 605 - 619 (2007/10/04)
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