56964-66-0Relevant academic research and scientific papers
3-Glucosylated 5-amino-1,2,4-oxadiazoles: Synthesis and evaluation as glycogen phosphorylase inhibitors
Donnier-Maréchal, Marion,Goyard, David,Folliard, Vincent,Docsa, Tibor,Gergely, Pal,Praly, Jean-Pierre,Vidal, Sébastien
, p. 499 - 503 (2015)
Glycogen phosporylase (GP) is a promising target for the control of glycaemia. The design of inhibitors binding at the catalytic site has been accomplished through various families of glucose-based derivatives such as oxadiazoles. Further elaboration of t
Amine-Responsive Disassembly of AuI–CuI Double Salts for Oxidative Carbonylation
Cao, Yanwei,Yang, Jian-Gong,Deng, Yi,Wang, Shengchun,Liu, Qi,Shen, Chaoren,Lu, Wei,Che, Chi-Ming,Chen, Yong,He, Lin
supporting information, p. 2080 - 2084 (2019/12/24)
A sensitive amine-responsive disassembly of self-assembled AuI-CuI double salts was observed and its utilization for the synergistic catalysis was enlightened. Investigation of the disassembly of [Au(NHC)2][CuI2] revealed the contribution of Cu-assisted ligand exchange of N-heterocyclic carbene (NHC) by amine in [Au(NHC)2]+ and the capacity of [CuI2]? on the oxidative step. By integrating the implicative information coded in the responsive behavior and inherent catalytic functions of d10 metal complexes, a catalyst for the oxidative carbonylation of amines was developed. The advantages of this method were clearly reflected on mild reaction conditions and the significantly expanded scope (51 examples); both primary and steric secondary amines can be employed as substrates. The cooperative reactivity from Au and Cu centers, as an indispensable prerequisite for the excellent catalytic performance, was validated in the synthesis of (un)symmetric ureas and carbamates.
Oxidative coupling of amines and carbon monoxide catalyzed by palladium complexes. Mono- and double carbonylation reactions promoted by iodine compounds.
Pri-Bar, Ilan,Alper, Howard
, p. 1544 - 1547 (2007/10/02)
Iodine is an effective promoter for the carbonylation of primary and secondary amines to ureas using palladium acetate as the catalyst and a base (e.g.K2CO3) in acetonitrile (3 h at 95 deg C and 2.7 atm).Oxamides are formed in excellent yields when secondary amines are carbonylated in the presence of iodide ion and oxygen, while primary amines give ureas as the principal product at 95 deg C, and oxamide at room temperature.
Palladium-Catalysed Synthesis of α-Methylene γ-Butyrolactams via Cyclisation of Homoallylic Chloroformamides
Henin, Francoise,Muzart, Jacques,Pete, Jean-Pierre
, p. 6339 - 6340 (2007/10/02)
3-Methylene 2-pyrrolidinones were prepared by intramolecular cyclisation of homoallylic chloroformamides catalysed by PdII or Pdo complexes.
