569669-97-2Relevant academic research and scientific papers
Synthesis of new calix[4]arene amide derivatives and investigation of their DNA cleavage activity
Oezkan, Seyda Cigdem,Yilmaz, Aydan,Oezmen, Ismail
, p. 25 - 31 (2014)
This study comprises the synthesis of new p-tert-butylcalix[4]arene with different amide functional groups and summarises an investigation of their DNA cleavage activities. The structural investigations of the synthesised compounds were examined by FTIR, 1H NMR, 13C NMR, elemental analysis and FAB-MS techniques. The interaction between these compounds and pBR322 plasmid DNA has been investigated via agarose gel electrophoresis and, according to the results, compounds 5, 7, 8 and 13 exhibit efficient DNA cleavage activity. In the electrophoresis images of 5, 7 and 8, Form IV which is small DNA fragment was observed in addition to supercoiled Form I, open circular Form II and linear Form III. 2013
Neutral guests complexation with calix[4]arenes preorganised by intramolecular McMurry reaction
Lhoták, Pavel,Zieba, Roman,Hromádko, Vit,Stibor, Ivan,Sykora, Jan
, p. 4519 - 4522 (2007/10/03)
The introduction of two aromatic aldehyde moieties into the lower rim of calix[4]arenes led to the precursors that were intramolecularly bridged in the presence of low-valent titanium agents (the McMurry reaction). These compounds, preorganised in the cone conformation, represent novel receptors with good complexation ability towards suitable neutral guest molecules both in solution and in the solid state. The influence of preorganisation and overall rigidity of receptor to the complexation process has been studied.
