569679-07-8Relevant academic research and scientific papers
A facile and efficient synthesis of 3,3-dimethyl isopropylidene proline from (+)-3-carene
Nair, Latha G.,Saksena, Anil,Lovey, Raymond,Sannigrahi, Mousumi,Wong, Jesse,Kong, Jianshe,Fu, Xiaoyong,Girijavallabhan, Viyyoor
, p. 1285 - 1288 (2010)
(Chemical Equation Presented) A highly efficient and practical route to 3,4-isopropylidene proline I, starting from (+)-3-carene, was developed. The three continuous stereocenters were constructed using the inherent chirality of the starting natural product 2. The overall yield for the 12-step synthesis is 34%. The optimized sequence leading to 1 has been successfully applied on a multigram scale, thereby establishing the practicality of this route.
