569682-62-8

Upstream product

• 1401109-46-3 benzyl N-(2,2-dimethoxyethyl)-N-(2-hydroxyethyl)carbamate 
• 1228671-69-9 methyl 2-((benzyloxycarbonyl)(2,2-dimethoxyethyl)amino)acetate 
• 114790-39-5 benzyl N-(2,2-dimethoxyethyl)carbamate 
• 501-53-1 benzyl chloroformate 
• 569682-60-6 benzyl N-(2,2-dimethoxyethyl)-N-(prop-2-en-1-yl)carbamate 

Downstream Products

• 569682-63-9 (-)-N-[2-(1,3-dioxo-1λ⁴,3λ⁴-dithian-2-ylidene)ethyl]-N-(2,2-dimethoxyethyl)carbamic acid benzyl ester 
• 569682-65-1 (+)-cis-(4S,3R)-4-benzylaminopyrrolidine-1,3-dicarboxylic acid-1-benzyl ester 
• 569682-64-0 (+)-[1'R,3'R]-1-benzyl-1',3'-dioxospiro[1',3'-dithiane-2',3-pyrrolo[3,4-c]isoxazole]-5-carboxylic acid benzyl ester 
• 1401109-47-4 C₁₆H₂₃NO₅ 
• 1401109-48-5 benzyl 2-hydroxy-6-vinylmorpholine-4-carboxylate 
• 1401109-50-9 benzyl 4-methyl-5-oxo-5,6-dihydropyridine-1(2H)-carboxylate 
• 1401109-49-6 C₁₄H₁₇NO₄ 
• 1401109-51-0 benzyl 5-hydroxy-4-methyl-5,6-dihydropyridine-1(2H)-carboxylate 
• 1401109-67-8 benzyl 5-hydroxy-4-methyl-5,6-dihydropyridine-1(2H)-carboxylate 

Relevant academic research and scientific papers

As the NS4B inhibitor benzofuran analogs (by machine translation)

The present invention discloses a kind of as NS4B benzofuran analogue inhibitors, in particular to the formula (I) below or a pharmaceutically acceptable salt thereof. (by machine translation)

Synthesis of new 4-methyl-3-piperidones via an iron-catalyzed intramolecular tandem isomerization-aldolisation process

A new versatile synthesis of 3-piperidones is described, starting from amino acids. It uses, as a key step, an iron carbonyl-mediated intramolecular tandem isomerization-aldolisation reaction. These new heterocycles appear as useful scaffolds for the total synthesis of various types of bioactive molecules.

The use of enantiomerically pure ketene dithioacetal bis(sulfoxides) in highly diastereoselective intramolecular nitrone cycloadditions. Application in the total synthesis of the beta-amino acid (-)-cispentacin and the first asymmetric synthesis of cis-(3R,4R)-4-amino-pyrrolidine-3-carboxylic acid.

Intramolecular 1,3-dipolar nitrone cycloaddition onto an enantiomerically pure ketene dithioacetal dioxide using a three-carbon tether gave the corresponding 5,5-disubstituted isoxazolidine as a single diastereomer in good yield. This reaction has been used as the key step in an asymmetric synthesis of the naturally occurring antibiotic, (-)-cispentacin. An asymmetric synthesis of 4-amino-pyrrolidine-3-carboxylic acid has also been carried out using the intramolecular nitrone cycloaddition as the stereocontrolling step.