56979-86-3

Usage

Uses

Used in Organic Synthesis:
(3,5-dimethylphenyl)cyanamide is used as a building block for the synthesis of various organic compounds. Its unique structure allows for the formation of new chemical bonds and the creation of complex molecules.
Used in Pharmaceutical Industry:
(3,5-dimethylphenyl)cyanamide is used as an intermediate in the synthesis of pharmaceuticals. Its ability to modify the properties of other chemicals makes it a valuable component in the development of new drugs.
Used in Agricultural Chemicals:
(3,5-dimethylphenyl)cyanamide is used as a modifier in the development of agricultural chemicals and agrochemicals. Its potential to alter the properties of other chemicals can lead to the creation of more effective and targeted products.
Used in Medicinal Chemistry Research:
(3,5-dimethylphenyl)cyanamide is used as a subject of study in medicinal chemistry and drug development. Its potential biological activity makes it an interesting compound for researchers seeking to understand its properties and applications in the field of medicine.

Upstream product

• 506-68-3 bromocyane 
• 108-69-0 3,5-dimethylaminoaniline 
• 97480-60-9 1-(3,5-dimethylphenyl)thiourea 

Relevant academic research and scientific papers

A PROCESS FOR THE PREPARATION OF THE COMPOUND N-(3,5-DIMETHYLPHENYL)-N'-(2-TRIFLUOROMETHYLPHENYL) GUANIDINE

The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N'-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II) with a compound of formula (III), in the presence of a polar organic solvent; a crystalline solid form of the compound of formula (I), in particular crystalline solid form A; to a pharmaceutical composition comprising them; and to their use as a medicament, in particular to the treatment of a condition mediated by Rho-GTPase cell proteins.

Synthesis of cyanamides from isoselenocyanates promoted by recyclable ionic liquid-supported (diacetoxyiodo)benzene

One-pot synthesis of cyanamides from isoselenocyanates through deselenisation promoted by ionic liquid-supported hypervalent iodine(III) reagent 1-(4-diacetoxyiodobenzyl)-3-methylimidazolium tetrafluoroborate [dibmim BF4 was developed. This approach provided a simple, mild and environmentally benign way to construct cyanamides in good yields. Moreover, powder Se and dibmim + BF4 could be easily recycled. It was the first example of [dibmim] + [BF4- to be used as a deselenising agent.

Copper-catalyzed one-pot synthesis of unsymmetrical arylurea derivatives via tandem reaction of diaryliodonium salts with N -arylcyanamide

An efficient "one-pot" approach to multiple substituted ureas from N-arylcyanamide and diaryliodonium salts has been presented. The two-step procedure involved the weak base-promoted chemoselective arylation of secondary amines with diaryliodonium and Cu-catalyzed nucleophilic addition of N-arylcyanamide with second diaryliodonium. The diverse unsymmetrical arylureas were obtained in up to 91% yield for 29 examples.

Synthesis and in vitro evaluation of N,N'-diphenyl and N-naphthyl-N'-phenylguanidines as N-methyl-D-aspartate receptor ion-channel ligands.

A series of N,N'-diphenyl and N-naphthyl-N'-phenyl guanidine derivatives was synthesized as potential N-methyl-D-aspartate (NMDA) receptor positron emission tomography (PET) ligands. The affinity of the different compounds was determined using in vitro receptor binding assays, and their log P values were estimated using HPLC analysis. The effect of N'-3 and N'-3,5 substitution on affinity and lipophilicity was examined. The K(i) values ranged from 1.87 to 839nM, while log P values between 1.22 and 2.88 were observed.