56980-16-6Relevant articles and documents
New polyacridine compounds: Synthesis of acridine dimers and tetramers
Filloux,Galy
, p. 1137 - 1139 (2001)
A series of 7,9-disubstituted acridine dimers and tetramers have been synthesized from nucleophilic attack of 2-bromomethyl-9-chloro-7-methoxy acridine 5 by different alkyl diamines.
Redox-neutral decarboxylative photocyclization of anthranilic acids
Huang, Huawen,Deng, Kun,Deng, Guo-Jun
supporting information, p. 8243 - 8247 (2020/12/29)
A mild metal-, catalyst-, and oxidant-free photoredox neutral system has been found to efficiently enable intramolecular decarboxylative cyclization of anthranilic acids. This facile protocol provides an alternative method for the synthesis of carbazoles. Mechanistic studies reveal a key photoinduced 6π-electrocyclization process and formic acid was released as the sole byproduct.
Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors
Cuny, Gregory D.,Robin, Maxime,Ulyanova, Natalia P.,Patnaik, Debasis,Pique, Valerie,Casano, Gilles,Liu, Ji-Feng,Lin, Xiangjie,Xian, Jun,Glicksman, Marcie A.,Stein, Ross L.,Higgins, Jonathan M.G.
scheme or table, p. 3491 - 3494 (2010/08/21)
Haspin is a serine/threonine kinase required for completion of normal mitosis that is highly expressed during cell proliferation, including in a number of neoplasms. Consequently, it has emerged as a potential therapeutic target in oncology. A high throughput screen of approximately 140,000 compounds identified an acridine analog as a potent haspin kinase inhibitor. Profiling against a panel of 270 kinases revealed that the compound also exhibited potent inhibitory activity for DYRK2, another serine/threonine kinase. An optimization study of the acridine series revealed that the structure-activity relationship (SAR) of the acridine series for haspin and DYRK2 inhibition had many similarities. However, several structural differences were noted that allowed generation of a potent haspin kinase inhibitor (33, IC50 50 400 nM) with a 5.4-fold selectivity over haspin was also identified.
Oxidative coupling of acridinones: Synthesis of new C2-symmetry atropisomers
Scarpellini-Charras, Karine,Boyer, Gerard,Filloux, Nathalie,Galy, Jean-Pierre
, p. 67 - 70 (2008/09/18)
(Chemical Equation Presented) The preparation of symmetric 2,2′-dimethoxy-10,10′-biacridinyl-9,9′-dione atropisomers were obtained by the oxidative coupling of 9(10H)-acridinone with 1,3-dibromo-5,5-dimethyl-imidazolidine-2,4-dione.
