56984-70-4

Upstream product

• 6287-38-3 3,4-dichlorobenzaldehyde 
• 40950-94-5 3-(3,4-dichloro-phenyl)-acrylic acid ethyl ester 
• 20883-95-8 3,4-Dichlor-zimtsaeure-methylester 
• 1202-39-7 3,4-dichlorocinnamic acid 

Downstream Products

• 880347-69-3 (2S-trans)-[3-(3,4-dichloro-phenyl)-oxiranyl]-methanol 
• 1136238-65-7 3-(3,4-dichlorophenyl)allyl methyl carbonate 
• 46118-00-7 3,4-Dichlor-cinnamylamin 
• 20850-23-1 Chloressigsaeure-(3,4-dichlorcinnamylamid) 
• 56984-69-1 Dimethyl-carbamic acid (E)-3-(3,4-dichloro-phenyl)-allyl ester 
• 56984-68-0 Methyl-carbamic acid (E)-3-(3,4-dichloro-phenyl)-allyl ester 
• 20850-12-8 3,4-Dichlor-cinnamylchlorid 

Relevant academic research and scientific papers

Intramolecular Sakurai Allylation of Geminal Bis(silyl) Enamide with Indolenine. A Diastereoselective Cyclization to Form Functionalized Hexahydropyrido[3,4- b]Indole

A fluoride-promoted intramolecular Sakurai allylation of geminal bis(silyl) enamide with indolenine has been developed. The reaction facilitates an efficient cyclization to give hexahydropyrido[3,4-b]indoles in good yields with high diastereoselectivity. The resulted cis, trans-stereochemistry further enables the ring-closing metathesis (RCM) reaction of two alkene moieties, giving a tetracyclic N-hetereocycle widely found as the core structure in akuammiline alkaloids.

Ternary Catalysis Enabled Three-Component Asymmetric Allylic Alkylation as a Concise Track to Chiral α,α-Disubstituted Ketones

Multicomponent reactions that involve interception of onium ylides through Aldol, Mannich, and Michael addition with corresponding bench-stable acceptors have demonstrated broad applications in synthetic chemistry. However, because of the high reactivity and transient survival of these in situ generated intermediates, the substitution-type interception process, especially the asymmetric catalytic version, remains hitherto unknown. Herein, a three-component asymmetric allylation of α-diazo carbonyl compounds with alcohols and allyl carbonates is disclosed by employing a ternary cooperative catalysis of achiral Pd-complex, Rh2(OAc)4, and chiral phosphoric acid CPA. This method represents the first example of three-component asymmetric allylic alkylation through an SN1-type trapping process, which involves a convergent assembly of two active intermediates, Pd-allyl species, and enol derived from onium ylides, providing an expeditious access to chiral α,α-disubstituted ketones in good to high yields with high to excellent enantioselectivity. Combined experimental and computational studies have shed light on the mechanism of this novel three-component reaction, including the critical role of Xantphos ligand and the origin of enantioselectivity.

Iridium-Catalyzed Enantioselective Allylic Substitution of Aliphatic Esters with Silyl Ketene Acetals as the Ester Enolates

Enantioselective allylic substitution with enolates derived from aliphatic esters under mild conditions remains challenging. Herein we report iridium-catalyzed enantioselective allylation reactions of silyl ketene acetals, the silicon enolates of esters, to form products containing a quaternary carbon atom at the nucleophile moiety and a tertiary carbon atom at the electrophile moiety. Under relatively neutral conditions, the allylated aliphatic esters were obtained with excellent regioselectivity and enantioselectivity. These products were readily converted into primary alcohols, carboxylic acids, amides, isocyanates, and carbamates, as well as tetrahydrofuran and γ-butyrolactone derivatives, without erosion of enantiomeric purity.

SULFONAMIDE COMPOUNDS

Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.

Certain 2,4-pentadienamide pestacides

The present application discloses pesticidally active compounds of formula I: or a salt thereof, wherein Q is an monocyclic aromatic ring, or Q is a dihalovinyl group or a group R7 --C=C-- where R7 is C1-4 alkyl, tri Csub