56990-57-9

Basic information

• Product Name: 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-
• Synonyms: 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-;8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonicacid;NSC 87877;XGMFVZOKHBRUTL-QURGRASLSA-N
• CAS NO: 56990-57-9
• Molecular Formula: C19H13N3O7S2
• Molecular Weight: 459.45
• Product Categories: Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP).
• Mol File: 56990-57-9.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.69g/cm³
• Refractive Index: 1.757
• Storage Temp.: Store at +4°C
• Solubility: ≥45.9 mg/mL in DMSO; insoluble in EtOH; ≥16.6 mg/mL in H2O with ultrasonic
• CAS DataBase Reference: 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-(56990-57-9)
• EPA Substance Registry System: 5-Quinolinesulfonic acid, 8-hydroxy-7-(6-sulfo-2-naphthylazo)-(56990-57-9)

Safety Data

• Hazardous Substances Data: 56990-57-9(Hazardous Substances Data)

Usage

Uses

NSC 87877 is an inhibitor of SHP2 and SHP1 protein tyrosine phosphatases

Biological Activity

Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC 50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μ M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.

InChI:InChI=1/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,21H,(H,24,25,26)(H,27,28,29)/b22-16+