57004-61-2

Upstream product

• 420-04-2 CYANAMID 
• 35589-32-3 3,4-dimethoxy-aniline; hydrochloride 
• 6315-89-5 3,4-dimethoxyaniline 

Downstream Products

• 884197-15-3 9-iodo-2-(3,4-dimethoxyphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one 
• 1350815-89-2 9-trifluoromethyl-2-(3,4-dimethoxyphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one 
• 1350815-90-5 9-fluoro-2-(3,4-dimethoxyphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one 

Relevant academic research and scientific papers

One-Pot Evolution of Ageladine A through a Bio-Inspired Cascade towards Selective Modulators of Neuronal Differentiation

A bio-inspired cascade reaction has been developed for the construction of the marine natural product ageladine A and a de novo array of its N1-substituted derivatives. This cascade features a 2-aminoimidazole formation that is modeled after an arginine post-translational modification and an aza-electrocyclization. It can be effectively carried out in a one-pot procedure from simple anilines or guanidines, leading to structural analogues of ageladine A that had been otherwise synthetically inaccessible. We found that some compounds out of this structurally novel library show a significant activity in modulating the neural differentiation. Namely, these compounds selectively activate or inhibit the differentiation of neural stem cells to neurons, while being negligible in the differentiation to astrocytes. This study represents a successful case in which the native biofunction of a natural product could be altered by structural modifications.

Cardiovascular activity of aromatic guanidine compounds.

A series of aromatic guanidines and several 1-phenylbiguanides was prepared and tested for cardiovascular (CV) effects in anesthetized dogs measuring heart rate, blood pressure, carotid artery blood flow, and myocardial force changes. The predominant CV effect at minimally effective dose was vasoconstriction unassociated with cardiac stimulation. The structure-activity relationships of the compounds were discussed comparing their structural similarities to the beta-phenylethylamines. The most potent members of the series were phenylguanidines substituted in the 3 and 4 positions on the aromatic nucleus with hydroxy or chloro groups. Preliminary mechanism studies indicated that the 3,4-dihydroxyphenylguanidines act at least partially by a direct alpha-adrenergic mechanism