57018-04-9 Usage
Uses
Different sources of media describe the Uses of 57018-04-9 differently. You can refer to the following data:
1. Agricultural fungicide.
2. Tolclofos-methyl is a non-systemic organophosphorus fungicide
with both protective and curative activities that control soil-borne diseases
caused by Rhizoctonia solani, Corticium rolfsii, Tphula incamata and Typhula
ishikariensis in/on potatoes, sugar beet, cotton and peanuts.
Definition
ChEBI: An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for co
trolling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani.
Metabolic pathway
Tolclofos-methyl underwent common degradation and metabolic pathways
in water, soil, plants and animals. These reactions are well
documented for most organophosphorus compounds and include oxidative
desulfuration, hydroxylation/oxidation of the 4-methyl group
to the alcohol and carboxylic acid, cleavage of the P-O-aryl linkage,
O-demethylation and conjugation. In addition to the above reactions,
photolytic isomerisation to the thionate (P=S) was also observed. A
schematic presentation of the primary metabolic pathways for tolclofosmethyl
is illustrated in Scheme 1.
Degradation
[14C-phenyl]Tolclofos-methyl(1) was stable to hydrolytic degradation at
pH 5, 7 and 9 at 22°C with DT50 values of 139, 417 and 238 days,
respectively. Higher temperature led to a more rapid hydrolysis and two
hydrolysis products were detected. O-Demethylation and oxidative desulfuration
were the major reactions to yield 2,6-dichloro-p-tolyl methyl
hydrogen phosphorothioate (2) and toclofos-methyl oxon (O-2,6-dichlorop-
tolyl O,O-dimethyl phosphate, 3), respectively. Cleavage of the P-O-aryl
linkage yielded 2,6-dichloro-4-methylphenol(4) as a minor degradation
product (WHO, 1994).
Tolclofos-methyl degraded in water under natural sunlight irradiation
with DT50 values of 44 days (in distilled water), 15-28 days (in natural
river and pond water) and less than 2 days in 2% acetone/water. The
major degradation reactions included oxidative desulfuration to yield
compound 3 and O-demethylation to yield compound 2. The major
photodegradation products in river and pond waters and soil thinlayer
surfaces were compounds 2, 3, 4 and the O-demethylated 3 (2,6-
dichloro-p-tolyl methyl hydrogen phosphate, 5) (Mikami et al., 1984).
In acetone solution, demethylation of the isomerisation product [2,6-
dichloro-p-tolyl O,S-dimethyl phosphorothioate (6)] yielded 2,6-dichlorop-
tolyl S-methyl hydrogen phosphorothioate (7) and 2,6-dichloro-p-tolyl
dihydrogen phosphate (8) as the major photodegradates (Mikami et al.,
1984).
Toxicity evaluation
Its acute oral toxicity is very low in comparison with
a thio-ester type of other organophosphorus fungicides
(edifenphos, iprobenfos, and pyrazophos).
Check Digit Verification of cas no
The CAS Registry Mumber 57018-04-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,0,1 and 8 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 57018-04:
(7*5)+(6*7)+(5*0)+(4*1)+(3*8)+(2*0)+(1*4)=109
109 % 10 = 9
So 57018-04-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H11Cl2O3PS/c1-6-4-7(10)9(8(11)5-6)14-15(16,12-2)13-3/h4-5H,1-3H3
57018-04-9Relevant articles and documents
PROCESS FOR PRODUCTION OF PURIFIED O-(2,6-DICHLORO-4-METHYL-PHENYL) O,O-DIMETHYL PHOSPHOROTHIOATE
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Page/Page column 4, (2011/10/12)
A process for producing a purified O—(2,6-dichloro-4-methylphenyl)—O,O-dimethyl phosphorothioate, the process comprising: the first step of bringing a crude O—(2,6-dichloro-4-methylphenyl)—O,O-dimethyl phosphorothioate into contact with an acid; and the second step of recovering the purified O—(2,6-dichloro-4-methylphenyl)—O,O-dimethyl phosphorothioate from the mixture obtained in the first step.
Composition for controlling harmful bio-organisms and method for controlling harmful bio-organisms using the same
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, (2008/06/13)
A composition for controlling harmful bio-organisms comprising (a) at least one imidazole compound represented by formula (I): wherein R represents a lower alkyl group or a lower alkoxy group; and n represents an integer of 1 to 5, as an active ingredient, and (b) at least one inorganic phosphorus compound and/or at least one fungicide for Phycomycetes as an active ingredient or (c) a spreader as an activity-enhancing ingredient, and a method for controlling harmful bio-organisms comprising applying the composition for controlling harmful bio-organisms onto harmful bio-organisms.
