5702-27-2Relevant academic research and scientific papers
Condition-determined multicomponent reactions of 1,3-dicarbonyl compounds and formaldehyde
Liu, Changhui,Shen, Meng,Lai, Bingbing,Taheri, Amir,Gu, Yanlong
, p. 652 - 660 (2015/02/19)
By means of changing the reaction parameters, different products could be generated selectively starting from the same combination of substrates involving 1,3-dicarbonyl compounds and formaldehyde. This strategy enabled us to access diverse molecules with
Reactions of trimethylsilyl-derived iodohydrins with electron-rich π-systems
Ishai, Eti,Shamai, Sarit,Feit, Ben-Ami
, p. 434 - 438 (2007/10/03)
Reactions of trimethylsilyl-derived iodohydrins of the type R1R2CH-CH(I)OTMS, with electron-rich olefins, and the effects of certain factors on these reactions, were studied. The trimethylsilyl-derived iodohydrins were obtained in situ by reacting R1R2CH-CHO (R1 = R2 = H; R1 = H, R2 = alkyl, phenyl) with TMSI. The corresponding trimethylsilyl enol ether derivatives (R1R2C=CH-OTMS), and 1,1-diarylethylenes were the olefins used. Aldehydes of the type RCH2-CH=O reacted smoothly in the presence of TMSI to yield the condensation product RCH2-CH=C(R)-CH=O. Both RCH(-CH=CAr2)2 and the cyclic acetal 5 were obtained as main products of the RCH=O-TMSI-CH2=CAr2 reaction system, depending on the [RCHO]:[TMSI]:[CH2=CAr2] concentration ratio. The mechanisms of formation for the various main products and by-products are discussed. TMSI substitutes, formed by reacting Me3SiCl with each of several Lewis acids, were also used.
