5702-82-9

Basic information

• Product Name: N-[4-(piperidin-1-ylsulphonyl)phenyl]acetamide
• Synonyms: N-[4-(piperidin-1-ylsulphonyl)phenyl]acetamide;N-[4-(Piperidinosulfonyl)phenyl]acetamide;Acetamide, N-(4-(1-piperidinylsulfonyl)phenyl)-;Ai3-32817;Einecs 227-187-3;4'-(1-Piperidinylsulfonyl)acetanilide, 97%;N-[4-(piperidin-1-ylsulfonyl)phenyl]acetamide
• CAS NO: 5702-82-9
• Molecular Formula: C₁₃H₁₈N₂O₃S
• Molecular Weight: 282.35862
• EINECS: 227-187-3
• Mol File: 5702-82-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.296g/cm³
• Refractive Index: 1.59
• CAS DataBase Reference: N-[4-(piperidin-1-ylsulphonyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(piperidin-1-ylsulphonyl)phenyl]acetamide(5702-82-9)
• EPA Substance Registry System: N-[4-(piperidin-1-ylsulphonyl)phenyl]acetamide(5702-82-9)

Safety Data

• Hazardous Substances Data: 5702-82-9(Hazardous Substances Data)

Usage

General Description

N-[4-(piperidin-1-ylsulphonyl)phenyl]acetamide is a compound with the chemical formula C14H20N2O3S. It is an amide derivative of piperidin-1-ylsulphonylphenylacetic acid. This chemical is used as an intermediate in the synthesis of pharmaceutical compounds. It has been studied for its potential use in the treatment of various diseases, including cancer and neurodegenerative disorders. N-[4-(piperidin-1-ylsulphonyl)phenyl]acetamide has a piperidine group, a sulphonyl group, and an acetamide group. Its precise mechanism of action and potential therapeutic applications are still being investigated, but it shows promise as a potential drug candidate for future medical research and development efforts.

InChI:InChI=1/C13H18N2O3S/c1-11(16)14-12-5-7-13(8-6-12)19(17,18)15-9-3-2-4-10-15/h5-8H,2-4,9-10H2,1H3,(H,14,16)

Upstream product

• 110-89-4 piperidine 
• 354551-99-8 C₁₄H₁₂N₂O₆S 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 6336-68-1 4-(piperidin-1-ylsulfonyl)aniline 
• 854476-87-2 1-(4-amino-3-thiocyanato-benzenesulfonyl)-piperidine 

Relevant articles and documents

Ammonium chloride-catalyzed four-component sonochemical synthesis of novel hexahydroquinolines bearing a sulfonamide moiety

Ammonium chloride as a very inexpensive and readily available reagent efficiently catalyzes one-pot four-component condensation of dimedone with aromatic aldehyde, malononitrile or ethyl cyanoacetate, and sulfonamide derivatives in ethanol at 70°C under ultrasonic irradiation to afford the corresponding 2-amino-4-aryl-1,4,5,6,7,8-hexahydroquinolines bearing a sulfonamide moiety in high yields. In comparison to conventional methods, high yields, easy work-up, and short reaction time are advantages of this sonochemical procedure. The effects of the catalyst, solvent, and temperature are assessed.

Synthesis and pharmacological evaluation of N-phenyl-acetamide sulfonamides designed as novel non-hepatotoxic analgesic candidates

In this paper we report the design, synthesis and pharmacological evaluation of a series of N-phenyl-acetamide sulfonamide derivatives (5a-g), planned by structural modification on the prototype paracetamol (1). In this series (5a-g), compound LASSBio-1300 (5e; ID50 = 5.81 μmol/kg) stands out as a new non-hepatotoxic analgesic drug candidate. The increase of area, volume and eletrostatic potential of paracetamol's analogues seems to be beneficial to the analgesic activity. Unlike paracetamol (1) and the other analogues (5a, 5d-g), compounds 5b and 5c presented an important anti-hypernociceptive activity associated to inflammatory pain.

NOVEL ADENOSINE A3 RECEPTOR AGONISTS

The invention realizes that a series of sulfonamido derivatives with a conserved uronamide group at the 5' position provide superior A3 receptor affinity as well as selectivity. These new adenosine agonists are sulfonamido deritatives N-substituted with aliphatic groups (cyclic or linear) or aromatic radicals.