57026-80-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-METHYLPHENYL)-3-(3-NITROPHENYL)PROP-2-EN-1-ONE is used as an intermediate in the synthesis of pharmaceuticals for its potential anti-inflammatory and antioxidant properties.
Used in Agrochemical Industry:
1-(4-METHYLPHENYL)-3-(3-NITROPHENYL)PROP-2-EN-1-ONE is used as an intermediate in the synthesis of agrochemicals to develop new compounds for agricultural applications.
Used in Medicinal Chemistry Research:
1-(4-METHYLPHENYL)-3-(3-NITROPHENYL)PROP-2-EN-1-ONE is used as a key compound in organic chemistry for exploring its potential applications in medicinal chemistry, including the development of new drugs and therapies.

InChI:InChI=1/C16H13NO3/c1-12-5-8-14(9-6-12)16(18)10-7-13-3-2-4-15(11-13)17(19)20/h2-11H,1H3/b10-7+

Upstream product

• 2096-86-8 p-Tolylaceton 
• 99-61-6 3-nitro-benzaldehyde 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 78743-73-4 [2-Benzoyl-3-(3-nitro-phenyl)-cyclopropyl]-p-tolyl-methanone 
• 57026-81-0 m-nitrobenzylidene-p-methylacetophenone dibromide 
• 1210051-88-9 3-(3-nitrophenyl)-3-(phenylthio)-1-p-tolylpropan-1-one 
• 1384736-88-2 (E)-1-(4-((1H-imidazol-1-yl)methyl)phenyl)-3-(3-nitrophenyl)prop-2-en-1-one 
• 84857-21-6 4-(3-Nitro-phenyl)-6-p-tolyl-pyrimidin-2-ylamine 

Relevant academic research and scientific papers

An eco-friendly synthesis of 2-pyrazoline derivatives catalysed by CeCl 3· 7 H 2O

Abstract: 1,3,5-triaryl-2-pyrazoline derivatives were synthesised by a condensation reaction between chalcones and phenyl hydrazine using cerium chloride heptahydrate as a catalyst. All these reactions were carried out in ethyl lactate (70%) as a green solvent. Easy and efficient work up, recyclability of solvent and catalyst are the key merits of this protocol. Graphical Abstract:: SYNOPSIS A facile protocol for the synthesis of 1,3,5-triaryl-2-pyrazolines is described. The solvent ethyl lactate, obtained from renewable sources, is biodegradable. The catalyst CeCl 3· 7 H 2O is a water-tolerant Lewis acid with low toxicity. Easy and clean work up, recyclable solvent and catalyst are merits of the protocol. The reaction works well for all systems giving good yields of the desired products.[Figure not available: see fulltext.].

2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF

The compounds of Formula (1) having topoisomerase inhibitory effect includes [Formula should be inserted here] wherein, R1 is selected from a group consisting of H, OR5, optionally substituted C1-C12 alkyl, haloalkyl, C2-C12alkenyl, C2-C12alkynyl, C1-C12alkyloxy, C1-C12haloalkyloxy, C2-C10 heteroalkyl, C3- C12 cycloalkyl, C3-C12cycloalkenyl, C2- C12heterocycloalkyl, C2-C2 heterocycloalkenyl, C6-C18aryl, and C1-C18heteroaryl; R2, R3 and R4 are independently selected from a group consisting of H, halogen, CN, - NO2, SH, CF3, OH, CO2H, CONH2, OCF3, optionally substituted C1-C12alkyl, optionally substituted C1-C12haloalkyl optionally substituted C2-C12alkenyl, optionally substituted C2- C12alkynyl, optionally substituted C1-C12alkyloxy, optionally substituted C1- C12haloalkyloxy, optionally substituted C2-C12heteroalkyl, optionally substituted C3- C12cycloalkyl, optionally substituted C3-C12 cycloalkenyl, optionally substituted C2-C12 heterocycloalkyl, optionally substituted C2-C12 heterocycloalkenyl, optionally substituted C6- C18aryl, and optionally substituted C1-C18heteroaryl; R5 is selected H, optionally substituted C1-C12alkyl, optionally substituted C2- C12alkenyl, optionally substituted optionally substituted C1-C12 haloalkyl, optionally substituted C3-C12cycloalkyl, optionally substituted C6- C18aryl, and optionally substituted C1- Ci18heteroaryl; or a pharmaceutically acceptable salt, N-oxide, or prodrug thereof.

Interactive free energy relationships for non-additive multiple substituent effects in base catalysed condensation of benzaldehydes with acetophenones: A kinetic study

The base-catalysed condensation of benzaldehydes with acetophenones is enhanced by electron-withdrawing substituents in both starting compounds.The magnitude of ρ-value obtained for various substituents in the benzaldehyde moiety decreases with the introduction of electron-withdrawing groups in the para position of acetophenone moiety.