57036-87-0Relevant academic research and scientific papers
Synthesis and antitumor screening of novel 3-phenylthiazolo [4,5-d]pyrimidin-2-thione derivatives
Becan, Lilianna,Wagner, Edwin
experimental part, p. 521 - 528 (2009/04/07)
A series of new derivatives of 3-phenylthiazolo[4,5-d]pyrimidine-2-thiones were synthesized by the cyclization of 4-amino-5-alkyl(aryl) carboxamido-2,3-dihydrothiazolo-2-thione with aromatic aldehydes. Amine moieties were substituted in position 7 of the obtained bicyclic compounds. The synthesized compounds were characterized by elemental analysis, IR, 1H-NMR, and 13C-NMR spectral data. Some of the newly synthesized compounds were selected by the US National Cancer Institute for in vitro antitumor screening. The two compounds 3d 7-chloro-5-(4-fluorophenyl)-3- phenyl-4,5-dihydro-3H-thiazolo[4,5-d]pyrimidine-2-thione and 4i 5-(2-chlorophenyl)-7-(4-fluorobenzylamino)-3-phenyl-4,5-dihydro-3H-thiazolo[4, 5-d]pyrimidine-2-thione proved to be the most active in the present study and their antitumor activities against 60 human tumor cell lines were described. ECV Editio Cantor Verlag.
The Reaction of Active Methylene Reagents With Sulfur and Phenyl Isothiocyanate: Novel Synthesis of Thiazole, Thiazolopyrimidine, and 4,5'-Bithiazolyl Derivatives
Mohareb, Rafat Milad,Wardakhan, Wagnat Wahba,El-Ablack, Fawzia Zakeria
, p. 747 - 760 (2007/10/02)
The active methylene reagents 1a-i reacted with phenyl isothiocyanate and sulfur to afford the thiazole derivatives 2a-i.The reactivity of 2a and 2f towards various chemical reagents was studied.
SYNTHESIS OF SOME THIAZOLOPYRIMIDINES
El-Dean, Adel M. Kamal
, p. 21 - 28 (2007/10/02)
4-Amino-3-phenyl-2-thioxothiazol-5-carboxamide (1) reacts with aromatic aldehydes to form thiazolopyrimidines (2a,b), and with acetic anhydride to thiazolopyrimidine (2c).Thiazolocarboxamides (1a,b) were converted to thiaz
