57072-36-3 Usage
Uses
Used in Molecular Biology:
Nucleoside Q is used as a modified nucleoside in tRNA for [application reason its role in the anticodon wobble position, which may have implications for protein synthesis and genetic information transfer].
Used in Bacterial Systems:
In bacteria, Nucleoside Q is used as a precursor for the production of 7-deazaguanosine (D201390) from GTP (G837905) for [application reason its involvement in the biosynthesis of essential biomolecules in bacterial cells].
Used in Eukaryotic Systems:
Nucleoside Q is used as a replacement for guanosine in the anticodon of tRNAsGUN of eukaryotes for [application reason its potential role in the regulation of protein synthesis and genetic information transfer in both cytoplasmic and mitochondrial tRNAs of eukaryotic cells].
Check Digit Verification of cas no
The CAS Registry Mumber 57072-36-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,0,7 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 57072-36:
(7*5)+(6*7)+(5*0)+(4*7)+(3*2)+(2*3)+(1*6)=123
123 % 10 = 3
So 57072-36-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H23N5O7/c18-17-20-14-10(15(28)21-17)6(3-19-7-1-2-8(24)11(7)25)4-22(14)16-13(27)12(26)9(5-23)29-16/h1-2,4,7-9,11-13,16,19,23-27H,3,5H2,(H3,18,20,21,28)/t7-,8-,9+,11+,12+,13+,16+/m0/s1
57072-36-3Relevant academic research and scientific papers
Kondo, Tadao,Okamoto, Kaoru,Ohgi, Tadaaki,Goto, Toshio
, p. 207 - 213 (1986)
The nucleoside Q (1) and its biosynthetic precursors, preQ0 (2) and preQ1 (3) were synthesized from the key intermediate, 6-bromo-2-diacetylamino-3,4-dihydro-3-methoxymethyl-5-methyl-7-(5-O-acetyl-2,3-O-isopropylidene-β-D-ribofuranosyl)-7H-pyrrolopyrimidin-4-one (6) by conversion of the methyl group on the base to 3S,4R,5S-4,5-dihydroxycyclopent-1-en-3-ylaminomethyl, cyano, and aminomethyl groups, respectively.
Synthesis of the transfer-RNA nucleoside queuosine by using a chiral allyl azide intermediate
Klepper, Florian,Jahn, Eva-Maria,Hickmann, Volker,Carell, Thomas
, p. 2325 - 2327 (2008/03/11)
Chilled out: Chiral allyl azides are rarely used in natural product synthesis because of their tendency to undergo a [3.3] sigmatropic rearrangement (see scheme, top). In allylic cyclopentenyl azides, this rearrangement can be suppressed at just 0°C, enabling a short convergent synthesis of the hypermodified transfer-RNA nucleoside queuosine. (Chemical Equation Presented).
