57073-10-6

Basic information

• Product Name: methyl 20-dihydroprednisolonate
• Synonyms: methyl 20-dihydroprednisolonate;(20R)-11β,17,20-Trihydroxy-3-oxopregna-1,4-dien-21-oic acid methyl ester;(20R)-11β,17α,20-Trihydroxy-3-oxo-1,4-pregnadiene-21-oic acid methyl ester;(20R)-3-Oxo-11β,17-dihydroxy-20-(hydroxy)pregna-1,4-diene-21-oic acid methyl ester;(20R)-3-Oxo-11β,17α,20-trihydroxypregna-1,4-diene-21-oic acid methyl ester;Methyl 11β,17α,20α-trihydroxy-3-oxo-1,4-pregnadien-21-oate;(20S)-11β,17,20-Trihydroxy-3-oxopregna-1,4-dien-21-oic acid methyl ester;(20S)-11β,17α,20-Trihydroxy-3-oxo-1,4-pregnadiene-21-oic acid methyl ester
• CAS NO: 57073-10-6
• Molecular Formula: C22H30 O6
• Molecular Weight: 0
• Mol File: 57073-10-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 580.4°Cat760mmHg
• Flash Point: 200.7°C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 6.88E-16mmHg at 25°C
• Refractive Index: 1.6
• CAS DataBase Reference: methyl 20-dihydroprednisolonate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 20-dihydroprednisolonate(57073-10-6)
• EPA Substance Registry System: methyl 20-dihydroprednisolonate(57073-10-6)

Safety Data

• Hazardous Substances Data: 57073-10-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C22H30O6/c1-20-8-6-13(23)10-12(20)4-5-14-15-7-9-22(27,18(25)19(26)28-3)21(15,2)11-16(24)17(14)20/h6,8,10,14-18,24-25,27H,4-5,7,9,11H2,1-3H3/t14-,15-,16-,17+,18?,20-,21-,22-/m0/s1

Upstream product

• 104008-69-7 21-methoxy,11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 
• 67-56-1 methanol 
• 50-24-8 prednisolon 

Relevant articles and documents

SYSTEMIC ACTIVITIES OF A NEW ANTI-INFLAMMATORY STEROID: METHYL 20-DIHYDROPREDNISOLONATE

The systematic activities of methyl 20-dihydroprednisolonate (1), a new local anti-inflammatory steroid synthesized by modifying the 17β-ketol side-chain of prednisolone, on pituitary-adrenal function and liver glycogen content were investigated in rats.The parent compound, prednisolone, administered intramuscularly, caused a significant dose-related decrease in plasma levels of corticosterone, adrenocorticotropic hormone (ACTH), and liver glycogen content in rats.In contrast, methyl 20-dihydroprednisolonate caused mild PA supression and liver glycogen depletion only at high doses.The steroid acid ester did not exert glycogenic activity, unlike prednisolone, in the adrenalectomized rats.

Prednisolone derivatives

Novel prednisolone derivatives modified at C-17,C-20 and/or C-21 positions. Many of the compounds are anti-inflammatory agents which do not significantly suppress the pituitary-adrenal axis.