57073-81-1

Basic information

• Product Name: 3-(2-phenylhydrazinylidene)piperidin-2-one
• CAS NO: 57073-81-1
• Molecular Formula: C₁₁H₁₃N₃O
• Molecular Weight: 203.2404
• Mol File: 57073-81-1.mol
• Article Data: 3

Chemical Properties

• Density: 1.23g/cm³
• Refractive Index: 1.627
• CAS DataBase Reference: 3-(2-phenylhydrazinylidene)piperidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-phenylhydrazinylidene)piperidin-2-one(57073-81-1)
• EPA Substance Registry System: 3-(2-phenylhydrazinylidene)piperidin-2-one(57073-81-1)

Safety Data

• Hazardous Substances Data: 57073-81-1(Hazardous Substances Data)

Upstream product

• 100-34-5 benzene diazonium chloride 
• 3731-16-6 3-carboethoxy-2-pyridone 
• 10444-33-4 ethyl 2-(2-cyanoethyl)-3-oxobutanoate 
• 19365-08-3 3-hydroxypiperidin-2-one 
• 16867-04-2 dihydroxypyridine 
• 17216-62-5 diethyl 2-(2-cyanoethyl)malonate 
• 41888-21-5 3-carboxy-2-piperidone 
• 62-53-3 aniline 
• 41907-06-6 piperidinedione 
• 100-63-0 phenylhydrazine 
• 100374-00-3 4-cyano-2-((E)-phenylhydrazono)-butyric acid ethyl ester 
• 100720-31-8 2-oxo-3-phenylazo-piperidine-3-carboxylic acid ethyl ester 

Downstream Products

• 17952-82-8 1,2,3,4-tetrahydronorharman-1-one 
• 343-94-2 tryptamine hydochloride 

Relevant articles and documents

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N6-Substituted Adenosine Receptor Agonists. Synthesis and Pharmacological Activity as Potent Antinociceptive Agents

Novel N6-(indol-3-yl)alkyl derivatives of adenosine were synthesized.The adenosine receptor affinity and the antinociceptive activity of these compounds were assessed in binding studies and the phenylbenzoquinone-induced writhing test.Most of these analogues exhibited a potent analgesic activity without side effects.Among them, compound 3c (UP 202-32) bound to A1 (Ki = 110 nM) and A2 (Ki = 350 nM) adenosine receptors in a specific manner since it did not interact with many other receptors, especially opioid binding sites.The antinociceptive activity in the phenylbenzoquinone assay (ED50 = 3.3 mg/kg po) was antagonized by 8-cyclopentyltheophylline, suggesting that an adenosinergic mechanism underlies the analgesic activity observed with this compound.The data obtained with these new N6-substituted adenosine receptor agonists emphasize the interest of such compounds in the treatment of pain.