57081-01-3

Usage

Uses

Used in Organic Synthesis:
3-Formyl benzamidine hydrochloride is used as a reagent for its ability to react with aldehydes and ketones, facilitating the formation of amides and imines. This makes it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 3-Formyl benzamidine hydrochloride is used as a key intermediate in the synthesis of various drug candidates. Its versatile reactivity allows for the creation of new compounds with potential therapeutic properties.
Used in Fine Chemicals Production:
3-Formyl benzamidine hydrochloride is utilized in the production of fine chemicals, where its reactivity contributes to the synthesis of specialty chemicals used in various applications, including but not limited to, fragrances, dyes, and other industrial chemicals.
Storage and Handling:
It is important to store 3-Formyl benzamidine hydrochloride in a cool, dry place away from light to maintain its stability and reactivity, ensuring its effectiveness in various applications.

InChI:InChI=1/C8H8N2O.ClH/c9-8(10)7-3-1-2-6(4-7)5-11;/h1-5H,(H3,9,10);1H

Upstream product

• 24964-64-5 3-Cyanobenzaldehyde 

Downstream Products

• 84441-68-9 2-(3-Amidinobenzyliden)indan-1,3-dion * H₃PO₄ 
• 126534-93-8 1,3-bis<(3'-amidinobenzylidene)amino>guanidine trihydrochloride 
• 84441-76-9 Bis<5,5-dimethyl-1,3-dioxocyclohex-2-yl>-3-amidinophenylmethan * H3PO4 
• 84441-91-8 C₂₈H₂₄N₆*2ClH 
• 60766-46-3 3-[1-Chloro-3-(4-methoxy-phenyl)-3-oxo-2-phenyl-propyl]-benzamidine 
• 84441-86-1 1-(3-Amidinophenyl)-2-phenylbut-1-en-3-on * H₃PO₄ 
• 84441-89-4 C₂₂H₂₀N₆*2ClH 

Relevant academic research and scientific papers

S-adenosylmethionine decarboxylase inhibitors: New aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone)

A series of 3-acylbenzamidine (amidino)hydrazones 7a-h, the corresponding (hetero)aromatic congeners 7i-p, and 3,3'-bis-amidino-biaryls 25a-e were synthesized. The hydrazones 7a-p were prepared by conversion of the corresponding acyl nitriles 1a,c-d,i,n-p to the imido esters 3a,c-d,i and the amidines 5a,c-d,h-i, followed by a reaction with aminoguanidine, or vice versa. Similarly, the biaryl 3,3'-dinitriles 23a-e were converted, via the imino esters 24a-c or the imino thioesters 27d-e, to the diamidines 25a-e. These new products are conformationally constrained analogues of methylglyoxal bis(guanylhydrazone) (MGBG). They are up to 100 times more potent as inhibitors of rat liver S-adenosylmethionine decarboxylase (SAMDC) and generally less potent inhibitors of rat small intestine diamine oxidase (DAO) than MGBG. Some of these SAMDC inhibitors, e.g., compounds 7a, 7e, 7i, 25a, and 25d, have shown antiproliferative effects against T24 human bladder carcinoma cells. These products, whose structure-activity relationships are discussed, are of interest as potential anticancer agents and drugs for the treatment of protozoal and Pneumocystis carinii infections.

Bis-(amidine phenyl)cyclohexanecarboxylic acid ketones, compositions containing same and method of use

Bis-(amidine phenyl)cyclohexanecarboxylic acid ketones are provided having the structure STR1 wherein R is hydrogen, lower alkyl or aryl and n is 0, 1 or 2, and acid-addition salts thereof. In addition, pharmaceutical compositions containing the above compounds and a method of using same to treat inflammatory conditions in mammalian species are also provided.