57089-40-4Relevant academic research and scientific papers
Reductive cyclization of enones by titanium(IV) aryloxide and a Grignard reagent
Quan, Long Guo,Cha, Jin Kun
, p. 8567 - 8569 (2001)
The titanium-mediated cyclization of δ,ε-enones by using dichlorotitanium diphenoxide-cyclohexylmagnesium chloride diastereoselectively afforded cis-substituted cyclopentanols and was thus found to parallel the stoichiometric and catalytic titanocene-mediated reactions.
Nickel(0)-catalyzed intramolecular reductive coupling of alkenes and aldehydes or ketones with hydrosilanes
Hayashi, Yukari,Hoshimoto, Yoichi,Kumar, Ravindra,Ohashi, Masato,Ogoshi, Sensuke
supporting information, p. 6237 - 6240 (2016/05/19)
A nickel(0)-catalyzed reductive coupling of aldehydes and simple alkenes with hydrosilanes has been developed. A variety of silyl-protected 1-indanol derivatives were prepared in a highly diastereoselective manner (up to >99:1 dr) by employing a combination of nickel(0)/N-heterocyclic carbene and triethylsilane. The present system was also applied to a reductive coupling with ketones. Preliminary results of a nickel(0)-catalyzed asymmetric three-component coupling reaction of an aldehyde, an alkene, and triethylsilane are also shown.
