57093-47-7

Upstream product

• 108-24-7 acetic anhydride 
• 467-04-9 oripavine 
• 57-27-2 MORPHIN 
• 639-47-4 morphine 6-Methyl Ether 
• 57093-46-6 3-acetoxy-4,5α-epoxy-6α-methoxy-17-methyl-morphin-7-ene 

Downstream Products

• 467-04-9 oripavine 
• 64643-76-1 4,5α-epoxy-3,14-diacetoxy-6-oxo-17-methylmorphinan 
• 20594-83-6 nalbuphine 
• 16590-41-3 Naltrexone 
• 465-65-6 Naloxone 
• 33522-95-1 noroxymorphone 
• 75660-23-0 3-acetyloxymorphone 
• 76-41-5 oxymorphone 

Relevant academic research and scientific papers

PROCESS FOR OBTAINING 3,14-DIACETYLOXYMORPHONE FROM ORIPAVINE

The present invention relates to a new process for obtaining 3,14-diacetyloxymorphone from oripavine, a process to transform the obtained 3,14-diacetyloxymorphone into a noroxymorphone and a process to transform said noroxymorphone into naloxone, naltrexone, nalbuphine, nalfurafine or nalmefene.

PROCESSES FOR THE PREPARATION OF MORPHINANE AND MORPHINONE COMPOUNDS

The present application describes processes for the synthesis of morphinane and morphinone compounds, useful as pharmaceutical agents. Also included are novel intermediates useful in the preparation of these compounds. The process comprises quaternization of oripavine to provide a mixture of the R- and S-isomeric (at the nitrogen) quaternary salts. The R-isomer is readily isolated and converted to various N-(R)-morphinane and N-(S)-morphinone compounds. The R-isomer, S-isomer or a mixture of R- and S-isomers may be demethylated and converted to various morphinane and morphinone compounds.