57097-45-7

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-1H-PYRROLE-2-CARBONITRILE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be chemically modified and incorporated into the structures of various medicinal compounds. Its presence in the synthesis process aids in the development of drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-CHLORO-1H-PYRROLE-2-CARBONITRILE serves as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its chemical structure allows for the creation of active ingredients that can be tailored to target and control specific pests or weeds, thereby enhancing crop protection.
Used in Organic Synthesis for Industrial Applications:
4-CHLORO-1H-PYRROLE-2-CARBONITRILE is utilized as a building block in organic synthesis for a variety of industrial applications. Its unique structure makes it a valuable component in the creation of specialty chemicals, dyes, and other organic compounds that are used across different industries, including plastics, textiles, and coatings.
Safety Precautions:
Given the potential hazards associated with 4-CHLORO-1H-PYRROLE-2-CARBONITRILE, it is crucial to handle this chemical with care. Appropriate personal protective equipment (PPE) should be worn, including gloves, safety goggles, and a lab coat, to minimize the risk of skin and eye contact. Additionally, handling should be done in a well-ventilated area or under a fume hood to prevent inhalation of vapors or dust. In case of accidental ingestion, inhalation, or skin contact, immediate medical attention is necessary.

Upstream product

• 72652-31-4 2,2,2-trichloro-1-(4-chloro-1H-pyrrol-2-yl)ethan-1-one 
• 57097-36-6 2-azido-5-chloro-pyridine 1-oxide 
• 54818-83-6 2-amino-5-chloropyridine N-oxide hydrochloride 
• 915229-96-8 4-chloro-1H-pyrrole-2-carboxylic acid amide 
• 57097-43-5 4-chloro-1-hydroxy-pyrrole-2-carbonitrile 

Relevant academic research and scientific papers

SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS

This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.

PHENYL-3-{ (3- (1H- PYRROL- 2 -YL) - [1 , 2 , 4] 0XADIAZ0L-5-YL] PIPERIDIN-1-YL}-METHANONE DERIVATIVES AND RELATED COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides new compounds of formula (I) as positive allosteric modulators of metabotropic receptors - subtype 5 ("mGluR5") which are useful for the treatment or prevention of central nervous system disorders such as for example, cognitive decline, both positive and negative symptoms in schizophrenia as well as other central or peripheral nervous system disorders in which the mGluR5 subtype of glutamate metabotropic receptor is involved. The invention is also directed to pharmaceutical compounds and compositions in the prevention or treatment of such diseases in which mGluKi is involved. W represents (C4-C7)cycloalkyl, (C3-C7)heterocycloalkyl , (C3-C7)heterocycloalkyl-(C1-C3)alkyl or (C3-C7)heterocycloalkenyl ring; represents a (C5-C7)heteroeycloalkyl, (C5-C7)heterocycloalkeiiyl ring or a heteroaryl group of formula (a), (b), (c), (d), (e), (f), (g), (i). Q denotes a cycloalkyl, an aryl or heteroaryl group of formula (j), (k), (l), (m), (n). A is azo -N=N-, ethyl, ethenyl, ethynyl, -NR8C(=O)-, -NR8C(=O)-O-, -NR8C(=O)-NR9, NR8S(=O)2-, -C(=O)NR8-, -O-C(=O)NR8-, -S-, -S(=O)-, -S(=O)2-, -S(C=O)2NR8-, -C(=0)-0-, -0-C(=0)-, -C(=NR8)NR9-, C(C=NOR8)NR9- , -NR8C(=NOR9)-, =N-0-, -0-N=CH- or a group aryl or heteroaryl of formula, (o), (p), (q), (r), (s), (t), (u), (v), (w), (x). The other substituents are defined in the claims.

Process for the synthesis of N-hydroxypyrroles, N-hydroxyimidazoles, and derivatives thereof

A process is described for the preparation of N-hydroxypyrrole-2-carbonitriles, N-hydroxyimidazole-2-carbonitriles, pyrrole-2-carbonitriles, and 3-substituted-2, 3-dihydro-2-pyrrolones by thermally decomposing 2-azidoheteroaromatic N-oxides. In the proces