57100-16-0

Basic information

• Product Name: 2,3-dihydroimidazo[2,1-a]phthalazin-6(5H)-one
• CAS NO: 57100-16-0
• Molecular Formula: C₁₀H₉N₃O
• Molecular Weight: 187.198
• Mol File: 57100-16-0.mol

Chemical Properties

• Density: 1.49g/cm³
• Refractive Index: 1.764
• CAS DataBase Reference: 2,3-dihydroimidazo[2,1-a]phthalazin-6(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydroimidazo[2,1-a]phthalazin-6(5H)-one(57100-16-0)
• EPA Substance Registry System: 2,3-dihydroimidazo[2,1-a]phthalazin-6(5H)-one(57100-16-0)

Safety Data

• Hazardous Substances Data: 57100-16-0(Hazardous Substances Data)

Usage

Bicyclic structure

The compound has a two-ring structure.

Nitrogen and oxygen atoms

The compound contains both nitrogen (N) and oxygen (O) atoms in its structure.

Molecular weight

The molecular weight of the compound is 173.17 g/mol.

Pharmacological activities

The compound has potential pharmacological activities, including antimicrobial, antiviral, and analgesic properties.

Therapeutic agent

It is being studied for its potential to act as a therapeutic agent for various diseases and conditions.

Utility in materials science

The compound may have utility in materials science.

Precursor in synthesis

The compound can be used as a precursor in the synthesis of other organic compounds.

Upstream product

• 23279-81-4 4-(2-Hydroxyethylamino)phthalazin-1(2H)-one 
• 23215-51-2 4-(2-acetoxy-ethylamino)-2H-phthalazin-1-one 
• 118189-82-5 Formic acid 2-[formyl-(4-oxo-3,4-dihydro-phthalazin-1-yl)-amino]-ethyl ester 
• 87365-18-2 2-(2-aminoethyl)-2,3-dihydrophthalazine-1,4-dione 

Downstream Products

• 98926-19-3 2-(2-benzoylaminoethyl)-4-hxdroxyphthalazin-1(2H)-one 
• 98911-53-6 2-(2-benzoylaminoethyl)-4-benzoyloxyphthalazin-1(2H)-one 
• 87365-29-5 2-(2-phthalimidoethyl)-2,3-dihydrophthalazinedione-1,4 
• 87365-29-5 2-[2-(4-Hydroxy-1-oxo-1H-phthalazin-2-yl)-ethyl]-isoindole-1,3-dione 

Relevant articles and documents

Substituent-dependent asymmetric induction in the ring transformation of 2,3-dihydroimidazo[2,1-a]phthalazin-4-ium-6-olates effected by acetic and propionic anhydrides

On the effect of acetic and propionic anhydrides 2,3-dihydroimidazo[2,1-a]phthalazin-4-ium-6-olates (1c-j) underwent ring transformation (1→7.8). Alternative mechanisms are applied to reason the characteristic substituent-dependent asymmetric induction observed for the transformations of the 2-monosubstituted precursors. The structures of products were determined by IR. MS. 1H- and 13C-NMR (1D- and 2D) measurements supported by single crystal X-ray analysis.

AMINOPHTHALAZINONE DERIVATIVES, XII METHODS FOR THE SYNTHESIS OF IMIDAZOPHTHALAZINE AND PYRIMIDOPHTHALAZINE RING SYSTEMS, II

Acyloxyethylamino- and acyloxypropylaminophthalazinones undergo cyclization in the molten state to give imidazophthalazinone (30) and pyrimidophthalazinone (31), respectively, via carboxylic acid elimination caused by the protoncatalyzed O-alkyl splitting effect of the ester group.In compounds containing the amide-NH structural unit (3-6) internal proton catalysis of type A occurs; the dicarboxylic acid hemiester derivatives of comounds substituted at N(2) (e.g., 25-29) react according to type B; and the O,N-diformyl-(17-20) and O-acetyl (21-24) derivatives substituted at N(2) can be cyclized by external proton catalysis of type C.Anhydride-forming dicarboxylic acids - when they acylate the N(1) atom of the tricycle (30,32-35) formed in the melt - decompose the imidazo and pyrimido rings according to a Bamberger-type reaction with the formation of imides (--38-40, 43-49).The ring system of pyrimidophthalazinone (31) resists the melting with dicarboxylic acids.

AMINOPHTHALAZINONE DERIVATIVES, VIII. METHODS FOR THE SYNTHESIS OF IMIDAZOPHTHALAZINE RING SYSTEMS, I. CYCLIZATION OF HYDROXYALKYLAMINOPHTHALAZINONES WITH MINERAL ACIDS

Hydroxyalkylaminophthalazinones (1, 3, 11c) undergo direct cyclization with haloid acids or sulfuric acid in rapid reactions.Depending on the length of the alkyl-amino chain, imidazo-phthalazinone (2), pirimidophthalazinone (4) and pyrrolidi