5711-73-9

Usage

Uses

Used in Pharmaceutical Research and Development:
5-Pyridin-3-yl-1,3,4-oxadiazol-2-ylamine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to interact with specific biological targets, making it a promising candidate for the development of new drugs.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 5-Pyridin-3-yl-1,3,4-oxadiazol-2-ylamine is utilized as a building block for the design and synthesis of novel bioactive molecules. Its ability to modulate the activity of enzymes or receptors contributes to the discovery of potential therapeutic agents.
Used in Drug Discovery:
5-Pyridin-3-yl-1,3,4-oxadiazol-2-ylamine is employed as a lead compound in drug discovery processes. Its pharmacological properties and potential to bind with biological targets make it a valuable tool for identifying new therapeutic agents with improved efficacy and selectivity.
Used in the Study of Biological Systems:
5-PYRIDIN-3-YL-1,3,4-OXADIAZOL-2-YLAMINE is used as a research tool to investigate the mechanisms of action of various biological targets. Its interaction with enzymes or receptors can provide insights into the regulation of cellular processes and the development of targeted therapies.
Overall, 5-Pyridin-3-yl-1,3,4-oxadiazol-2-ylamine is a versatile chemical with a wide range of applications in the scientific and pharmaceutical fields, making it an essential component in the development of innovative therapeutic agents and the advancement of our understanding of biological systems.

InChI:InChI=1/C7H6N4O/c8-7-11-10-6(12-7)5-2-1-3-9-4-5/h1-4H,(H2,8,11)

Upstream product

• 13370-80-4 pyridine-3-carboxaldehyde semicarbazone 
• 500-22-1 3-pyridinecarboxaldehyde 
• 14397-23-0 nicotinoyl thiosemicarbazide 

Relevant academic research and scientific papers

Synthesis of a Series of Novel 2-Amino-5-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole Derivatives as Potential Anticancer, Antifungal and Anti-bacterial Agents

Objective: The objective of the present study was to prepare the 5-substituted 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole derivatives and evaluate their potential anticancer, antibac-terial and antifungal activities. Methods: Twenty-seven derivatives were synthesized by iodine-mediated cyclization of semicarba-zones or thiosemicarbazones obtained from condensation of semicarbazide or thiosemicarbazide and aldehydes. The structures were confirmed by1H-NMR,13C-NMR and MS spectra. The antibacterial and antifungal activities were evaluated by diffusion method and the anticancer activities were evaluated by MTT assay. Results: Twenty-seven derivatives have been synthesized in moderate to good yields. A number of derivatives exhibited potential antibacterial, antifungal and anticancer activities. Conclusion: Compounds (1b, 1e and 1g) showed antibacterial activity against Streptococcus faecal-is, MSSA and MRSA with MIC value ranging between 4 to 64 μg/mL. Compound (2g) showed anti-fungal activity against Candida albicans (8 μg/mL) and Aspergillus niger (64 μg/mL). Compound (1o) exhibited high cytotoxic activity against HepG2 cell line (IC50 value 8.6 μM) which is compara-ble to the activity of paclitaxel, and is non-toxic on LLC-PK1 normal cell line. The structure activity relationship and molecular docking study of the synthesized compounds have also been reported.

Green synthesis of 2-amino-5-substituted-1,3,4-oxadiazoles at the platinum anode in acetic acid

The electroorganic synthesis of 2-amino-5-substituted-1,3,4-oxadiazoles from the anodic oxidation of semicarbazone has been carried out at platinum anode in acetic acid under constant potential electrolysis in an undivided cell. This is an environmentally benign method in the field of synthetic organic chemistry. The products are characterized by IR, 1H and 13C NMR, and elemental analysis.