571165-05-4Relevant academic research and scientific papers
Direct C-H arylation of purines: Development of methodology and its use in regioselective synthesis of 2,6,8-trisubstituted purines
Cerna, Igor,Pohl, Radek,Klepetarova, Blanka,Hocek, Michal
, p. 5389 - 5392 (2006)
Direct C-H arylation of purines to position 8 by diverse aryl iodides was achieved with Pd catalysis in the presence of CuI and Cs2CO 3. The methodology is general and efficient and was applied in the consecutive regioselective synth
An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines
Hocek, Michal,Dvorakova, Hana
, p. 5773 - 5776 (2007/10/03)
Fe-catalyzed cross-coupling reactions of 9-substituted or protected 2,6-dichloropurines with 1 equiv of methylmagnesium chloride gave regioselectively 2-chloro-6-methylpurines in good yields. The same reactions with 3 equiv of methylmagnesium chloride or
