571165-77-0

Upstream product

• 204703-68-4 2',5'-bis(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)acetophenone 
• 490-78-8 2,5-Dihydroxyacetophenone 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 1026606-23-4 (E)-1-[2,5-Bis-(tetrahydro-pyran-2-yloxy)-phenyl]-3-(4-dimethylamino-phenyl)-propenone 

Downstream Products

• 215095-40-2 4'-dimethylamino-2,7-dihydroxyflavone 

Relevant academic research and scientific papers

A novel optochemical sensor for Fe3+ by an intramolecular charge-transfer fluorescence probe: 4-dimethylamino-2′,5′- dihydroxyehalcone

4-Dimethylamino-2′,5′-dihydroxychaleone (DMADHC), a typical compound that exhibits excited-state intramolecular charge-transfer (ICT) characteristics and possesses good photo-physical properties, is synthesized and used as fluoroionophore for a Fe3+

Synthesis, biological evaluation and in silico metabolic and toxicity prediction of some flavanone derivatives

Flavones chemically are anthoxanthins, occur either in the free state or as glycosides associated with tannins (flavanoids). Flavanoids (derivatives of flavone) possess various pharmacological activities and due to its xanthine-oxidase enzyme inhibitory effect it also has superoxide-scavenging activities. A series of 2-phenyl-2,3-dihydrochromon-4-one derivatives (flavanone derivatives) were synthesized from chalcones by cyclization method and their activities were evaluated against some gram positive and gram-negative bacteria. IR, NMR and CHN analysis confirmed the structure of the synthesized compounds. The results of the antibacterial studies shows that compounds 2b, 2e, 2f and 2h possess activity against many bacterial strains. Among that the compound (2h) has remarkable activity against all strains viz. 25 μg/ml inhibitory concentration against S. aureus, S. sonnei, E. coli, S. typhimurium and V. cholerae. Compound 2f possess minimum inhibitory concentration of 200 μg/ml against E. coli and S. typhimurium and 25 μg/ml against S. sonnei, S. dysenteriae and V. cholerae. In silico metabolic and toxicity study of the synthesized compounds were performed and the predicted result showed that the compound having hydroxyl functional group undergo sulfate and O-glucuronide conjugation reaction and methoxy derivatives undergo demethylation reaction. The biologically active compounds are free of toxicity in oncogene, teratogen, sensitivity and immunotoxicity.

Cytotoxic 2',5'-dihydroxychalcones with unexpected antiangiogenic activity.

A series of 2',5'-dihydroxychalcones were synthesized and evaluated for cytotoxicity against tumor cell lines and human umbilical venous endothelial cells (HUVEC). It was found that chalcones with electron-withdrawing substituents on the B ring exhibited potent cytotoxicity against a variety of tumor cell lines while compounds with electron-releasing groups were less potent in general. Those compounds with B ring replaced by extended or heteroaromatic rings exhibited significant bioactivity. Several compounds were shown to have marked cytotoxic selectivity towards HUVECs. Especially, among the synthesized compounds, 2-chloro-2',5'-dihydroxychalcone (2-3) showed the highest selectivity index up to 66 in comparison to HCT116 cells. This compound also exhibited strong inhibitory effects on the HUVEC tube formation in an in vitro model. When administered into BDF1 mice bearing Lewis lung carcinoma cells at 50 mg kg(-1) day(-1), 2-3 was found to inhibit the growth of tumor mass by 60.5%.

The complexation of flavone derivatives with alkali and alkaline earth metal cations studied by spectroscopic methods

A new kind of fluoroionophore, typified by flavone quasi-crown ether [4'-(dimethylamino)-3,6-(tetraethylene glycol)flavone] and flavone lariat- crown ether, were synthesized and characterized. The photophysical changes upon complexation with alkali and al