571167-33-4Relevant academic research and scientific papers
Palladium-Catalyzed γ-C(sp3)?H Arylation of Thiols by a Detachable Protecting/Directing Group
Jin, Likun,Wang, Jianchun,Dong, Guangbin
, p. 12352 - 12355 (2018)
Reported herein is a palladium-catalyzed, directed γ-C(sp3)?H arylation of protected thiols. The key is to utilize Michael acceptors as a dual reagent to install a protecting/directing group on thiols by a thiol-Michael click reaction, and remove it later under basic conditions. The C?H arylation proceeds with high functional-group tolerance and the deprotected thiols can be further transformed into other sulfur-containing compounds. This unique mode of activation could open the door for site-selective functionalization of thiols or other sulfur-containing compounds at unactivated positions.
Facile introduction of SH group on aromatic substrates via electrophilic substitution reactions
Becht, Jean-Michel,Wagner, Alain,Mioskowski, Charles
, p. 5758 - 5761 (2007/10/03)
Herein, we describe a mild and efficient two-step procedure to introduce a thiol group on aromatic substrates. First, reaction with an activated sulfoxide leads to an arylsulfonium salt intermediate. Then, two successive β-elimination-based dealkylation reactions afford the desired arylthiols in good to excellent yields.
