57119-17-2

Basic information

• Product Name: (1R,8-syn)-1,5α-Dimethyl-8-[2-(3-isopropylphenyl)ethyl]-6-oxabicyclo[3.2.1]octan-7-one
• Synonyms: (1R,8-syn)-1,5α-Dimethyl-8-[2-(3-isopropylphenyl)ethyl]-6-oxabicyclo[3.2.1]octan-7-one
• CAS NO: 57119-17-2
• Molecular Formula: C₂₀H₂₈O₂
• Molecular Weight: 300.43512
• Mol File: 57119-17-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1R,8-syn)-1,5α-Dimethyl-8-[2-(3-isopropylphenyl)ethyl]-6-oxabicyclo[3.2.1]octan-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,8-syn)-1,5α-Dimethyl-8-[2-(3-isopropylphenyl)ethyl]-6-oxabicyclo[3.2.1]octan-7-one(57119-17-2)
• EPA Substance Registry System: (1R,8-syn)-1,5α-Dimethyl-8-[2-(3-isopropylphenyl)ethyl]-6-oxabicyclo[3.2.1]octan-7-one(57119-17-2)

Safety Data

• Hazardous Substances Data: 57119-17-2(Hazardous Substances Data)

Upstream product

• 113375-17-0 ((1S,5R,8R)-1,5-Dimethyl-7-oxo-6-oxa-bicyclo[3.2.1]oct-8-yl)-acetaldehyde 
• 92778-26-2 ((1S,5R,8R)-1,5-Dimethyl-7-oxo-6-oxa-bicyclo[3.2.1]oct-8-yl)-acetic acid 
• 113375-20-5 (1S,5R,8R)-8-[2-Hydroxy-2-(3-isopropyl-phenyl)-ethyl]-1,5-dimethyl-6-oxa-bicyclo[3.2.1]octan-7-one 
• 134454-01-6 Methyl (1R,2R)-2-<2-(3-Isopropylphenyl)ethyl>-1-methyl-3-oxo-1-cyclohexanecarboxylate 
• 134454-00-5 Methyl (1R,2S)-2-<2-(3-Isopropylphenyl)ethyl>-1-methyl-3-oxo-1-cyclohexanecarboxylate 
• 134365-19-8 (R)-2-(3-Hydroxy-propyl)-5-(3-isopropyl-phenyl)-2-methyl-3-nitromethyl-pentanoic acid methyl ester 
• 81049-21-0 2-(3-isopropylphenyl)acetic acid 
• 68480-22-8 3-isopropyl-phenethyl alcohol 
• 72646-50-5 2-(3-Isopropylphenyl)ethyl Bromide 
• 134365-17-6 Methyl (1R,2S,3R)-1,3-Dimethyl-1-hydroxy-2<2-(3-isopropylphenyl)-ethyl>cyclohexanecarboxylate 
• 75399-83-6 (1R,2R,3S)-2-[2-(3-Isopropyl-phenyl)-ethyl]-1,3-dimethyl-cyclohexane-1,3-dicarboxylic acid monomethyl ester 

Downstream Products

• 65894-44-2 9.10-Secoabieta-8.11.13-trien-10.18-diol 

Relevant articles and documents

A new seco-abietane-type diterpene from the stem bark of Picea glehni

A new seco-abietane-type diterpenoid, 13S-hydroxy-9-oxo-9,10-seco-abiet- 8(14)-en-18,10α-olide (1) along with a known lignan compound, pinoresinol (2) was isolated from the stem bark of Picea glehni (Fr. Schm.) Masters. Spectroscopic methods and chemical conversions were used to establish the structure of 1. In order to assess their cancer chemopreventive potential, the inhibition of Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) was examined for compound 1, its synthetic analogue, 9,10-seco-8S,13S-epoxy-abiet-8(14)-en-18,10α-olide (1a) and 2. The inhibitory effect of 1a on EBV-EA induction was strong (0, 20.7, 67.1 and 89.2% inhibition at 1000, 500, 100 and 10 mol ratio/TPA). The IC 50 of 1a was 226 mol ratio/32 pmol/TPA.

Stereocontrolled Total Synthesis of (+/-)-9,10-Secoabieta-8,11,13-trien-18,10-olide: A Minor Component of Distilled Tall Oil

A simple and efficient stereocontrolled total synthesis of (+/-)-9,10-secoabieta-8,11,13-trien-10,18-olide (1a), involving the use of an aromatic ring as the latent carboxylic acid functionality, is described.