Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]is a complex organic compound with a unique chemical structure. It belongs to the class of pyrimidinones and is characterized by its tricyclic structure with various functional groups, including a cyclopentyl, a methyl, and a piperazinyl group. Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]is of interest due to its potential applications in the pharmaceutical industry, particularly as a therapeutic agent for various medical conditions.
571190-22-2
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Basic information
- Product Name: Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]-
- Synonyms: Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]-;8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one;8-Cyclopentyl-5-methyl-2-[[(5-piperazin-1-ylpyridin-2-yl)]amino]-8H-pyrido[2,3-d]pyrimidin-7-one
- CAS NO:571190-22-2
- Molecular Formula: C22H27N7O
- Molecular Weight: 405.49608
- EINECS: N/A
- Product Categories: N/A
- Mol File: 571190-22-2.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 651.3±65.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.301±0.06 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: -20°C, Inert atmosphere
- Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
- PKA: 8.66±0.10(Predicted)
- CAS DataBase Reference: Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]-(CAS DataBase Reference)
- NIST Chemistry Reference: Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]-(571190-22-2)
- EPA Substance Registry System: Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]-(571190-22-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 571190-22-2(Hazardous Substances Data)
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571190-22-2 Usage
Uses
Used in Pharmaceutical Industry:Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]is used as a therapeutic agent for the treatment of various medical conditions, particularly cancer. Its complex structure allows it to interact with specific cellular targets, such as cyclin-dependent kinases (CDKs), which play a crucial role in cell cycle regulation and are often dysregulated in cancer cells. By inhibiting these kinases, the compound can potentially halt the progression of the disease and provide a novel treatment option for patients.
Used in Cancer Treatment:
Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]is used as a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6 for the treatment of breast cancer. It has been identified as an impurity of Palbociclib (P139900), also known as compound number PD-0332991, which is an experimental drug developed by Pfizer. By targeting CDK4 and CDK6, Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]- can disrupt the cell cycle and prevent the uncontrolled proliferation of cancer cells, offering a promising approach to combat breast cancer.
Additionally, the compound may also have potential applications in other industries, such as in the development of new drug delivery systems or as a component in the synthesis of other pharmaceutical agents. However, further research and development are required to fully understand its potential and optimize its use in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 571190-22-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,7,1,1,9 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.Calculate Digit Verification of CAS Registry Number 571190-22:
(8*5)+(7*7)+(6*1)+(5*1)+(4*9)+(3*0)+(2*2)+(1*2)=142
142 % 10 = 2
So 571190-22-2 is a valid CAS Registry Number.
571190-22-2Upstream product
571190-22-2Downstream Products
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Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]-
