57145-14-9

Usage

Uses

Used in Pharmaceutical Industry:
α-(4-Chloro-benzyl)-isobutyric acid is used as an intermediate in the synthesis of various pharmaceuticals for its versatile chemical properties, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
α-(4-Chloro-benzyl)-isobutyric acid is used as an active ingredient in agrochemicals for its ability to inhibit the growth of certain bacteria and fungi, helping to protect crops and enhance agricultural productivity.
Used in Medical Research:
α-(4-Chloro-benzyl)-isobutyric acid is used in medical research for its potential antitumor properties, with studies exploring its ability to target and inhibit the growth of cancer cells.
Used in Antioxidant Research:
α-(4-Chloro-benzyl)-isobutyric acid is also used in antioxidant research due to its potential to combat oxidative stress and related diseases, making it a subject of interest for scientists working on novel antioxidant therapies.

Upstream product

• 14305-27-2 3-(4-chlorophenyl)-2,2-dimethylpropanoic acid methyl ester 
• 622-95-7 4-chlorobenzyl bromide 

Downstream Products

• 63293-86-7 3-(4-chlorophenyl)-2,2-dimethylpropanoic acid chloride 
• 80692-06-4 3-(4-chlorophenyl)-2,2-dimethylpropanoic acid 2-oxopropyl ester 
• 80691-94-7 3-(4-chlorophenyl)-2,2-dimethylpropanoic acid 2-aminopropyl ester 
• 80692-17-7 3-(4-chlorophenyl)-2,2-dimethylpropanoic acid N-methyl-4-piperidyl ester 
• 1308788-41-1 3-(4-chlorophenyl)-2,2-dimethyl-N-(pyridin-2-ylmethyl)propanamide 
• 1308788-88-6 3-(4-chlorobenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione 
• 1429896-40-1 2-(4-chlorobenzyl)-3-(4-methoxyphenyl)-2-methyl-N-(quinolin-8-yl)propanamide 
• 1429896-54-7 3-(4-chlorophenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide 

Relevant academic research and scientific papers

Palladium-catalyzed 2-pyridylmethyl-directed β-C(sp3)–H activation and cyclization of aliphatic amides with gem-dibromoolefins: A rapid access to γ-lactams

The direct Pd-catalyzed β-C(sp3)–H activation and cyclization of aliphatic amides bearing a removable 2-pyridylmethyl directing group with gem-dibromoolefins is described for the first time to construct a variety of γ-lactams. The resulting products with Z- and E-configurations can be easily separated and purified after the reaction, demonstrating the effectiveness and applicability of the method herein developed.

Sulfoximine assisted Pd(II)-catalyzed bromination and chlorination of primary β-C(sp3)-H bond

S-Methyl-S-2-pyridyl-sulfoximine (MPyS) directed bromination and chlorination of the 1°-β-C(sp3)-H bond of MPyS-N-amides is realized under the influence of N-Br/Cl-phthalimides and a Pd(II)-catalyst. The sequential halogenation and acetoxylation of α-dimethyl MPyS-N-amides constructs highly functionalized α-trisubstituted aliphatic acid derivatives. The MPyS directing group is cleaved from the halogenated products and recovered. (Chemical Equation Presented).

β-Arylation of carboxamides via iron-catalyzed C(sp3)-H bond activation

A 2,2-disubstituted propionamide bearing an 8-aminoquinolinyl group as the amide moiety can be arylated at the β-methyl position with an organozinc reagent in the presence of an organic oxidant, a catalytic amount of an iron salt, and a biphosphine ligand at 50 C. Various features of selectivity and reactivity suggest the formation of an organometallic intermediate via rate-determining C-H bond cleavage rather than a free-radical-type reaction pathway.

Highly regioselective carbonylation of unactivated C(sp3)-H bonds by ruthenium carbonyl

The regioselective carbonylation of unactivated C(sp3)-H bonds of aliphatic amides was achieved using Ru3(CO)12 as a catalyst. The presence of a 2-pyridinylmethylamine moiety in the amide is crucial for a successful reaction. The reaction shows a preference for C-H bonds of methyl groups as opposed to methylene C-H bonds and tolerates a variety of functional groups. The stoichiometric reaction of an amide with Ru 3(CO)12 gave a dinuclear ruthenium complex in which the 2-pyridinylmethylamino moiety was coordinated to the ruthenium center in an N,N manner.

Indaneacetic acid derivatives

This invention provides new compounds of formula I, STR1 wherein R1 is lower alkyl, R2 is hydrogen or lower alkyl, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl, R5 is hydrogen, chlorine or lower alkyl, and each of R6 and R7 is hydrogen, or, when R5 is hydrogen, R6 may also be chlorine or lower alkyl, and R7 chlorine or lower alkyl, Useful as anti-phlogistic and anti-arthritic agents.