57154-91-3Relevant academic research and scientific papers
Chemically Stable, Lipophilic Prodrugs of Phosphoramide Mustard as Potential Anticancer Agents
Kwon, Chul-Hoon,Moon, Ki-Young,Baturay, Nesrine,Shirota, Frances N.
, p. 588 - 592 (2007/10/02)
Benzyl phosphoramide mustard (3), 2,4-difluorobenzyl phosphoramide mustard (4), and methyl phosphoramide mustard (5) were examined as lipophilic, chemically stable prodrugs of phosphoramide mustard (2).These phosphorodiamidic esters are designed to underg
Synthesis, hydrolytic reactivity, and anticancer evaluation of N-and O-triorganosilylated compounds as new types of potential prodrugs
Chiu,Chang,Ozkan,Zon,Fichter,Phillips
, p. 542 - 551 (2007/10/02)
N- and O-Triorganosilylated compounds related to various anticancer agents were synthesized for evaluation as potential anticancer prodrugs. 1H-NMR and UV kinetic measurements of hydrolytic desilylation were used to correlate relative rates of structural unmasking with steric bulk about the silicon reaction center. The tert-butyldimethylsilyl ester of chlorambucil and a number of O-triorganosilylated carbamate derivatives of nor-nitrogen mustard showed significant activity against P-388 lymphocytic leukemia in mice.
