57160-49-3Relevant academic research and scientific papers
In situ slow release of isocyanates: Synthesis and organocatalytic application of N-acylureas
Singh, Atul K.,Chawla, Ruchi,Yadav, Lal Dhar S.
, p. 5099 - 5102 (2013/09/02)
A novel, efficient, and operationally simple one-pot synthesis of both, symmetrical and unsymmetrical N-acylureas from carboxamides and in situ generated isocyanates (from N,N-dibromo-p-toluenesulfonamide) in the presence of a mild base at rt is reported. The protocol avoids the tedious isolation and purification steps of hazardous isocyanates. The first application of these acylureas to the catalysis through hydrogen bonding is also demonstrated.
Halogenation Using Quatenary Ammonium Polyhaloides. IX. One-Step Syntheses of Acylureas and Carbamates from Amides by Use of Tetrabutylammonium Tribromide and DBU
Fujisaki, Shizuo,Tomiyasu, Kazushi,Nishida, Akiko,Kajigaeshi, Shoji
, p. 1401 - 1403 (2007/10/02)
The reaction of amides with tetrabutylammonium tribromide (TBA Br3) (0.5 equiv) and DBU (one equiv) in dichloromethane at room temperature gave N-substituted acylureas in fairly good yields.In the presence of alcohols, the reaction of amides with TBA Br3 (one equiv) and DBU (two equiv) gave N-substituted carbamates.
